Table 2: Subdistribution hazard ratios for the association of central venous catheter‐related bloodstream infection with interventions and patient and central venous catheter characteristics – univariable and multivariable regression analyses Univariable regression analysis Multivariable regression analysis with time‐dependent trend Multivariable regression analysis without time‐ dependent trend HH intervention 0.46 (0.27 – 0.79) 0.37 (0.16 – 0.87) 0.59 (0.43 – 0.81) CVC intervention 0.61 (0.44 – 0.86) 1.16 (0.63 – 2.16) 0.46 (0.28 – 0.74) Both interventions 0.39 (0.28 – 0.56) 0.47 (0.27 – 0.83) 0.33 (0.24 – 0.47) Sex Male Female 1 1.02 (0.81 – 1.28) 1 1.04 (0.84 – 1.28) Age (years) < 30 30‐49 50‐69 ≥ 70 0.64 (0.36 – 1.14) 0.96 (0.70 – 1.33) 1 0.90 (0.70 – 1.15) 0.59 (0.34 – 1.03) 0.98 (0.72 – 1.32) 1 0.94 (0.75 – 1.19) Type of admissiona Medical Surgical Unscheduled surgical 1.36 (1.00 – 1.87) 1 1.67 (1.20 – 2.35) 1.28 (0.89 – 1.84) 1 1.70 (1.18 – 2.46) Type of ICU Cardiothoracic surgery & coronary care Infectious diseases Intermediate careb Medical Medical‐surgical Neurology Neurosurgery Surgery Vascular surgery 1.02 (0.64 – 1.61) 0.92 (0.44 – 1.91) 4.26 (0.58 – 31.3) 1.02 (0.64 – 1.65) 1 1.26 (0.60 – 2.62) 1.51 (0.76 – 3.01) 1.58 (0.49 – 5.14) 0.46 (0.06 – 3.60) 1.71 (1.04 – 2.82) 0.79 (0.37 – 1.68) 2.75 (0.45 – 16.8) 1.14 (0.72 – 1.82) 1 1.99 (0.98 – 4.02) 1.88 (1.04 – 3.40) 1.88 (0.54 – 6.51) 0.80 (0.10 – 6.48) ICU stayc until insertion (days) 0 1‐5 6‐20 >20 1.89 (1.15 – 3.11) 1 2.80 (2.17 – 3.62) 3.02 (2.16 – 4.23) 1.90 (1.13 – 3.20) 1 2.31 (1.76 – 3.03) 2.17 (1.54 – 3.04) BSI at the time of CVC insertion Yes No 6.84 (5.50 – 8.52) 1 5.86 (4.63 – 7.43) 1 Place of insertion ICU Operating room Elsewhere 1 0.52 (0.37 – 0.72) 0.86 (0.52 – 1.39) 1 0.73 (0.46 – 1.14) 0.89 (0.51 – 1.54)
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