Table M4 Hazard ratios (HR) for the subset with known Apache II‐scores, with 95% confidence intervals. Sub‐distribution HR (95% CI) HHi (intervention 1) 0.11 (0.02 – 0.66) CVCi (intervention 2) 0.93 (0.37 – 2.38) COMBi (intervention 3) 0.22 (0.08 – 0.61) Apache II score (first ICU admission) <10 1.17 (0.63 – 2.17) 10 ‐ 19 1.45 (0.97 – 2.16) 20 ‐29 1 ≥ 30 0.81 (0.48 – 1.38) Intracluster correlation coefficient - Hand hygiene compliance The intracluster correlation coefficient (ICC) for hospitals during the baseline period, without accounting for covariates, was 0.18. The ICC increased to 0.28 during the intervention period. - CVC insertion score The ICC for hospitals during the baseline period was 0.22. The ICC increased to 0.37 during the intervention period - CRBSI The ICC cannot be calculated References Supplementary material 1. McLaws ML, Berry G (2005) Nonuniform risk of bloodstream infection with increasing central venous catheter‐days. Infect Control Hosp Epidemiol 26:715‐719 2. Wolkewitz M, Cooper BS, Bonten MJ, Barnett AG, Schumacher M (2014) Interpreting and comparing risks in the presence of competing events. BMJ 349:g5060 3. Beyersmann J, Gastmeier P, Schumacher M (2014) Incidence in ICU populations: how to measure and report it? Intensive Care Med 40:871‐876 4. Latouche A, Allignol A, Beyersmann J, Labopin M, Fine JP (2013) A competing risks analysis should report results on all cause‐specific hazards and cumulative incidence functions. J Clin Epidemiol 66:648‐653 5. Lau B, Cole SR, Gange SJ (2009) Competing risk regression models for epidemiologic data. Am J Epidemiol 170:244‐256 6. Schumacher M, Allignol A, Beyersmann J, Binder N, Wolkewitz M (2013) Hospital‐acquired infections‐‐appropriate statistical treatment is urgently needed! Int J Epidemiol 42:1502‐1508 7. Fine JPaG, R.J. (1999) A Proportional Hazards Model for the Subdistribution of a Competing Risk. Journal of the American Statistical Association 94:496‐509 8. Resche‐Rigon M, Azoulay E, Chevret S (2006) Evaluating mortality in intensive care units: contribution of competing risks analyses. Crit Care 10:R5
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