Overall 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 p‐ value** CVC days CRBSI incid. per 1000 CVC days Application Total parenteral nutrition 21.4 79473 265 3.3 21.1 19.5 22.5 23.6 21.4 20.2 23.2 18.2 20.9 24.5 18.0 <0.0001 Antibiotics 47.2 146768 207 1.4 36.0 45.2 53.8 55.7 56.7 46.3 41.2 38.6 42.0 46.5 60.0 <0.0001 Dialysis 12.1 40220 54 1.3 16.6 21.0 14.9 12.7 13.4 11.1 10.6 11.1 10.8 11.8 13.8 <0.0001 Hemodynamic monitoring 55.7 149429 187 1.3 64.0 52.7 55.4 61.6 61.6 61.3 58.8 50.9 47.6 43.4 50.8 <0.0001 Other applications 10.3 24274 34 1.4 8.5 9.1 7.0 7.2 6.6 9.3 8.4 13.8 16.0 14.5 12.3 <0.0001 Catheter duration (median) 5 5 6 6 6 5 5 5 5 5 5 5 <0.0001 * Percentages for patient‐based characteristics were calculated for patients. ** p‐values were calculated with multinomial multilevel regression and indicate whether the distribution of the variable over the categories differed between calendar years. For this aim catheter duration was categorized into 6 categories (2‐4, 5‐7, 8‐10, 11‐13, 14‐16 and > 16 days). *** ICU days and non‐ICU days of catheters present both in and outside the ICU were attributed to ICU and non‐ICU respectively. 9 223 The effect of a CRBSI prevention bundle in the Netherlands
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