Table II: Association of patient and central venous catheter (CVC) characteristics with central line‐related bloodstream infection (CRBSI) risk. Results of univariable (all variables) and multivariable regression analysis (variables retained in the final model). All patients and CVCs CVCs (when) in ICU CVCs (when) outside ICU Univariable analysis Multivariable analysis Univar. Multivar. Univar. Multivar. HR$ (95% CI$) HR (95% CI) HR 95% CI HR (95% CI) HR 95% CI HR (95% CI) Sex (male vs female) 1.23 (1.02‐1.48) 1.24 (1.03‐1.49) 1.20 (0.91‐1.59) 1.19 (0.89‐1.58) 1.32 (1.04‐1.69) 1.28 (1.01‐1.62) Age <45 years ref. ref. ref. ref. ref. ref. 45‐65 0.90 (0.62‐1.32) 0.89 (0.61‐1.30) 0.65 (0.41‐1.05) 0.68 (0.42‐1.11) 1.31 (0.69‐2.46) 1.31 (0.69‐2.48) ≥ 65 years 0.99 (0.69‐1.41) 0.97 (0.68‐1.39) 0.64 (0.41‐0.99) 0.66 (0.42‐1.03) 1.56 (0.85‐2.87) 1.62 (0.88‐2.98) Insertion vein Subclavian ref. ref. ref. ref. ref. Jugular 1.23 (1.01‐1.50) 1.51 (1.24‐1.85) 1.91 (1.33‐2.74) 2.12 (1.47‐3.05) 1.12 (0.87‐1.43) Femoral 1.10 (0.85‐1.43) 1.58 (1.18‐2.11) 1.93 (1.31‐2.84) 2.01 (1.36‐2.9) 0.72 (0.42‐1.22) Application Total parenteral nutrition 2.36 (1.98‐2.82) 2.26 (1.86‐2.75) 1.27 (0.92‐1.76) 1.44 (1.02‐2.04) 3.50 (2.61‐4.69) 3.27 (2.42‐4.42) Antibiotics 0.54 (0.44‐0.65) 0.54 (0.44‐0.67) 0.65 (0.48‐0.88) 0.64 (0.47‐0.87) 0.50 (0.39‐0.65) 0.61 (0.47‐0.81) Dialysis 0.78 (0.59‐1.04) 0.63 (0.45‐0.88) 1.01 (0.73‐1.41) 0.57 (0.30‐1.10) Hemodynamic monitoring 0.67 (0.55‐0.81) 0.75 (0.61‐0.92) 0.92 (0.70‐1.21) 0.65 (0.48‐0.90) Other 1.03 (0.72‐1.48) 1.18 (0.70‐1.99) 0.93 (0.54‐1.60) Per additional year of participation* 0.94 (0.89‐1.00) 0.93 (0.87‐0.99) 0.92 (0.84‐1.00) 0.90 (0.82‐0.98) 0.97 (0.89‐1.06) Per calendar year 0.95 (0.91‐1.00) 0.91** (0.86‐0.97) 0.91 (0.84‐0.98) 0.89** (0.82‐0.96) 0.99 (0.92‐1.060 Compliance Overall bundle (1_6) 1.15 (0.91‐1.45) 1.12 (0.78‐1.60) 1.35 (0.96‐1.91) Insertion bundle*** 0.84 (0.57‐1.25) 0.99 (0.54‐1.81) 0.62 (0.37‐1.03) 0.50 (0.30‐0.85) Maintenance bundle *** 1.23 (0.97‐1.55) 1.28 (1.00‐1.62) 1.11 (0.78‐1.59) 1.59 (1.13‐2.24) 1.68 (1.19‐2.36) $ HR = hazard ratio; CI = confidence interval * year with >80% registration of bundles ** Multivariable results when in model instead of participation years *** In multivariable analysis together in initial model 226 Chapter 9
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