Supplement Case definition of Central venous catheter‐Related Bloodstream Infection (CRBSI) in the PREZIES Surveillance CRBSI: microbiologically‐confirmed CVC‐related bloodstream infection Clinical symptoms [fever (>38°), shivers, hypotension (systolic pressure <100 mmHg)] And peripheral venous blood culture is positive And positive (semi)quantitative culture of the Central Venous Catheter (CVC)‐ tip [>15 colony‐forming units (cfu)] with identical microorganism or quantitative blood culture ratio CVC blood sample/peripheral blood sample > 5; or differential delay of positivity of blood cultures: CVC blood sample culture positive two hours or more before peripheral blood culture (blood samples drawn simultaneously); or positive culture with identical microorganism from pus from CVC insertion site And absence of other infection with identical microorganism. CRBSI, category 1 Clinical symptoms [fever (>38°), shivers, hypotension (systolic pressure <100 mmHg)] And positive qualitative culture of the CVC tip And peripheral venous blood culture positive with identical microorganism And absence of other infection with identical microorganism. CRBSI, category 2 Clinical symptoms [fever (>38°), shivers, hypotension (systolic pressure <100 mmHg)] And positive (semi)quantitative culture of the CVC tip (>15 cfu) And no peripheral venous blood sample obtained, however arterial blood culture positive with identical microorganism And absence of other infection with identical microorganism. CRBSI, category 3 Clinical symptoms [fever (>38°), shivers, hypotension (systolic pressure <100 mmHg)] And peripheral venous blood culture is positive or no blood cultures taken And positive qualitative or quantitative culture of the CVC tip with identical microorganism 9 231 The effect of a CRBSI prevention bundle in the Netherlands
RkJQdWJsaXNoZXIy MTk4NDMw