or no culture of the CVC tip taken And fever disappears within 24h after CVC removal And absence of other infection with identical microorganism. CRBSI, category 4 Clinical symptoms [fever (>38°), shivers, hypotension (systolic pressure <100 mmHg)] And positive peripheral venous blood culture And CVC remains in situ And fever disappears within 48 h after start of antibiotic treatment. And absence of other infection with identical microorganism Notes: • Catheter‐related: the CVC was in situ < 48 hours before the onset of the BSI • In Dutch clinical practice, CRBSI is usually investigated by culturing both peripheral blood and the CVC tip. If less optimal (laboratory) methods are used, the diagnostic CRBSI categories 1‐4 are available (hierarchical structure). • The CRBSI categories specify the laboratory method of culturing the CVC (semi‐ qualitative of quantitative) and the body site from which the blood culture is drawn (peripheral venous or arterial). • The CVC and blood samples are preferentially drawn simultaneously or within 24 hours. 232 Chapter 9
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