ABSTRACT Background: The Dutch PREZIES surveillance scheme for catheter‐related bloodstream infection (CR‐BSI) collects data on infection rates and related risk factors. Aim: To evaluate risk factors for CR‐BSI. Methods: Hospitals collected data for intensive care units (ICU) or for the entire hospital. All short‐term central venous catheters (CVC), including Swan‐Ganz catheters, present for ≥ 48 hours were surveyed, except in cases when bacteraemia was present at insertion. CVCs were monitored until infection, removal or death for up to 28 days. Data were collected on 3,750 catheters and 29,003 CVC days. Findings: Of the CVCs surveyed, 1.6% (95% confidence interval (CI) 1.2‐2.0) resulted in CR‐BSI, representing 2.0/1000 CVC days (95% CI 1.6‐2.6). Multi‐variate analysis revealed that the length of ICU stay prior to CVC insertion, insertion in the jugular or femoral vein, and use of the CVC to deliver total parenteral nutrition increased the risk of CR‐BSI, whereas use of the CVC to deliver antibiotics decreased the risk of CR‐BSI. Conclusion: Attention to these risks has the potential to reduce the incidence of CR‐BSI. 44 Chapter 3
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