All uncuffed CVCs and Swan‐Ganz catheters present for ≥ 48 hours in patients over one year of age were included, unless they were inserted during a culture‐proven bacteraemia. Box 1: PREZIES criteria for central venous catheter‐related bloodstream infection (CR‐BSI) Broviac/Hickman catheters and Port‐a‐Caths were excluded. Hospitals could choose to record all such patients or only those in specific ICU(s). Multiple hospital admissions per patient could be included as well as multiple concurrent central lines per patient. Each central line was monitored until infection or removal for up to 28 days. The following data were recorded: type of hospital (university hospital or not); ICU level (level 1‐3, indicating increasing complexity of care); demographic data; specialty of the treating physician; APACHE II score if in ICU; dates of hospital admission and discharge; ICU admission and discharge; CVC insertion and removal; insertion ward (operating room/recovery room, ICU or other); insertion vein; coating; surgery (in the week before insertion of the first CVC); single or multi‐lumen; acute or elective insertion (‘acute’ being defined as an emergency insertion with suboptimal infection prevention measures); replacement ≤ or > 24 h; CVC application [total parenteral nutrition (TPN), PREZIES criteria for CR-BSI: o clinical symptoms (fever (> 38°), shivers, hypotension (systolic pressure<100)) and o absence of other infection with identical micro-organism and either o positive (semi) quantitative culture of the catheter tip (>15 cfu) and o peripheral venous blood culture positive for identical micro-organism or or o positive (semi) quantitative culture of the catheter tip (>15 cfu) and o arterial blood culture positive for identical micro-organism or o no blood culture done or o positive qualitative culture of the catheter tip and o peripheral venous blood culture positive for identical micro-organism or o no cultures done or o positive qualitative culture of the catheter tip only or o positive peripheral venous blood culture only and o fever disappears within 24 hrs after removal of the catheter or o positive peripheral venous blood culture and o catheter remains in situ and o fever disappears within 48 hrs after start of antibiotic treatment 46 Chapter 3
RkJQdWJsaXNoZXIy MTk4NDMw