Table of contents Chapter 1 Introduction ..................................................................................................................... 7 Part I HAI in the early 2000s: expansion of surveillance programmes Chapter 2 Incidence and risk factors of device-associated infections and associated mortality at the intensive care in the dutch surveillance system. ................................ 21 Chapter 3 Catheter application, insertion vein and length of ICU stay prior to insertion affect the risk of catheter-related bloodstream infection ............................................ 43 Chapter 4 Using flexible methods to determine risk factors for ventilator-associated pneumonia in the Netherlands. .................................................................................... 59 Chapter 5 Prevalence of nosocomial infections in the Netherlands, 2007-2008: results of the first four national studies. .................................................................................. 89 Chapter 6 Mortality review as a tool to assess the contribution of healthcare-associated infections to death: results of a multicentre validity and reproducibility study, 11 European Union countries, 2017 to 2018 .............................................................. 105 Part II Prevention of HAI: improving compliance to best practices Chapter 7 Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentred study to reduce central venous catheter-related bloodstream infections ....................................................... 145 Chapter 8 Hand hygiene improvement of individual healthcare workers – Results of the multicentre PROHIBIT study........................................................................................ 193 Chapter 9 The effect of an intervention bundle to prevent central venous catheter-related bloodstream infection in a national programme in the Netherlands. ...................... 215 Chapter 10 General discussion.... ................................................................................................ 237 Closing pages................................................................................................................................ 263 Summary ..................................................................................................................................... 265 Samenvatting ................................................................................................................................ 271 Dankwoord .................................................................................................................................... 279 About the author........................................................................................................................... 281 List of publications ........................................................................................................................ 283
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