Patients Perc. of patients Ventilator days Perc. of ventilator days Number of VAPs Perc. patients with VAP Incidence density per 1000 ventilator days HR (95% CI) p‐value Intubation department ICU 417 44.4 3618 46.0 25 6.0 6.9 Ref OR 396 42.1 3505 44.5 40 10.1 11.4 1.45 (0.88 ‐2.38) 0.14 Recovery 5 0.5 50 0.6 0 0.0 0.0 0.0 (0.00 – inf) 1.00 Other 122 13.0 699 8.9 16 13.1 22.9 2.31 (1.19 – 4.48) 0.01 Inhalation trauma No 924 98.3 7738 98.3 79 8.5 10.2 1 Yes (burns & other) 15 1.6 131 1.7 2 13.3 15.3 1.89 (0.44 – 7.84) 0.40 burns 1 0.1 4 0.1 0 0.0 0.0 other 14 1.5 127 1.6 2 14.3 15.7 Missing 1 0.1 3 <0.1 0 0.0 0.0 Stress Ulcer prophylaxis No 346 36.8 2316 29.4 22 6.4 9.4 Ref Protonpump inhibitors 561 59.7 5296 67.3 56 10.0 10.6 1.07 (0.62 – 1.87) 0.80 H2‐antagonists 33 3.5 260 3.3 3 9.1 11.5 1.77 (0.45 – 6.89) 0.41 Sucralphate 0 0.0 0 0.0 Corticosteroid use (eq. > 10 mg prednisone) No 489 52.0 4139 52.6 50 10.2 12.1 Ref Neutropenia No 905 96.3 7535 95.7 77 8.5 10.2 Ref Yes 32 3.4 322 4.1 3 9.4 9.3 0.71 (0.22 – 2.26) 0.59 Missing 3 0.3 15 0.2 1 33.3 66.7 Participation year 1 370 39.4 2996 38.1 35 9.5 11.7 Ref 2 284 30.2 2435 30.9 26 9.2 10.7 0.70 (0.41 – 1.19) 0.19 3 203 21.6 1687 21.4 18 8.9 10.7 0.52 (0.29 – 0.95) 0.03 4 83 8.8 754 9.6 2 2.4 2.7 0.17 (0.04 – 0.72) 0.02 Yes 451 48.0 3733 47.4 31 6.9 8.3 0.69 (0.43 – 1.12) 0.13 4 71 Risk factors for VAP using flexible methods
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