Table C: Hazard ratios for univariate models of time‐dependent covariates Current exposure‐risk model (current effect of the current value of the time‐dependent variable) 1‐day delay exposure‐risk model (current effect of the current value of the time‐dependent variable) 2‐day delay exposure‐risk model (current effect of the current value of the time‐dependent variable) WCE exposure‐risk model (current effect of the current and past values of the time‐dependent variable for the best‐fitting model) Exposure ‐risk model selected for final model LOCF venti‐ lator days (%) 1 HR 95% CI p‐value AIC HR 95% CI p‐value AIC HR 95% CI p‐ value AIC Relevant exposure window & number of knots2 HR & 95% CI p‐ value 3 AIC Sedation score 977 983 986 22 days Fig 3A 0.162 980 Current 1 741 (9.4) 0.07 (0.01, 0.52) 0.010 0.11 (0.01, 0.83) 0.032 0.16 (0.02, 1.22) 0.077 1 knot for all 5 2 1095 (13.9) 0.44 (0.19, 1.01) 0.051 0.50 (0.20, 1.26) 0.141 0.47 (0.16, 1.37) 0.167 3 944 (12.0) 0.39 (0.18, 0.87) 0.020 0.31 (0.12, 0.77) 0.012 0.47 (0.20, 1.14) 0.094 4 1208 (15.3) 0.41 (0.20, 0.83) 0.013 0.52 (0.27, 1.02) 0.058 0.39 (0.18, 0.84) 0.015 5 1932 (24.5) 0.67 (0.38, 1.19) 0.175 0.67 (0.38, 1.18) 0.167 0.70 (0.41, 1.20) 0.192 6 1952 (24.8) Ref Ref Ref Feeding mode 989 990 969 8 days Fig 3G 0.929 989 2‐day delay No feeding 592 (7.5) 0.00 (0.00, inf) 0.998 0.46 (0.06, 3.39) 0.445 2.26 (1.06, 4.78) 0.034 1 knot for both (comb ined) Parenteral 1248 (15.9) Ref Ref Ref Enteral&Both 6032 (76.6) 0.92 (0.51, 1.65) 0.772 0.87 (0.48, 1.58) 0.651 0.88 (0.46, 1.67) 0.692 82 Chapter 4
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