108 Chapter 4 Figure S3. a-d No increase in total or TSPO+ microglia and astrocytes are observed in control versus AD. e An increase in CD68+IBA1+ cells is observed in AD. f,g No increases in mean TSPO signal in microglia and astrocytes is observed in AD relative to control. h No differences are observed in mean TSPO signal in microglia associated with plaques compared to mean TSPO signal in microglia that are distant from plaques. Figure S4. a Representative image of an acute lesion in marmoset EAE. b,c IBA1+ and TSPO+IBA1+ cells are increased in acute and subacute lesions compared to white matter in control marmoset. Planned Concentration (nM) Measured Concentration (nM) XDB173 XDB173 Cell supernatant 1.78nM XBD 2.0 Cell supernatant 1.78nM XBD 1.9 Cell supernatant 22.5nM XBD 21.8 Cell supernatant 22.5nM XBD 20.6 Cell supernatant 284nM XBD 290.6 Cell supernatant 284nM XBD 318.8 Figure S5. Planned and measured concentrations of XBD173 in medium for experiments described in Figures 8d and 8e.
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