109 TSPO in neurodegeneration Table S1. Clinical details of AD and control cases Case Age/sex Diagnosis Region Braak stage PMD, h:min AD cases 1 81/F AD HC (anterior) 6 05:30 2 88/F AD HC (anterior) 6 06:19 3 62/M AD HC (anterior) 6 06:15 4 64/F AD HC (anterior) 6 06:30 5 76/M AD HC (anterior) 6 04:40 Controls 1 65/F NDC HC 2 07:10 2 90/F NDC HC 3 06:10 3 81/F NDC HC 3 05:30 4 77/M NDC HC (anterior) 2 04:30 5 81/F Ischemic changes HC (anterior) 4 05:50 Abbreviations: F – female; HC – hippocampus; M – male; NDC – non-demented control; PMD – postmortem delay. Table S2. Clinical details of ALS and control cases Case Age/ sex Diagnosis DD, months Cause of death PMD, h Primary onset SPC levels ALS short disease duration 1 70/F sALS 6 respiratory failure < 12 leg C/T/L 2 63/M sALS 7 respiratory failure < 12 leg C/T/L 3 61/F sALS 12 euthanasia < 12 arm C/T/L 4 60/M sALS 12 euthanasia < 12 arm C/T/L 5 81/M sALS 12 respiratory failure < 12 respiratory T/L 6 84/F sALS 13 euthanasia < 12 bulbar C/T 7 56/F sALS 16 euthanasia < 12 leg C/T/L ALS medium disease duration 8 43/M sALS 36 unknown < 12 arm C/T/L 9 64/F fALS 57 pneumonia < 12 leg C/T/L 10 68/M sALS 87 euthanasia < 12 arm C/T/L 11 79/M sALS (C9orf72) 107 pneumonia < 12 arm C/T/L Controls 12 60/M bricker-bladder N/A lung embolism < 24 N/A C/T/L 13 63/M kidney carcinoma N/A lung embolism < 24 N/A C/T/L 14 81/F heart ischemia N/A endocarditis < 24 N/A C/T/L 15 63/F adeno-carcinoma N/A paralytic ileus < 24 N/A C/T/L 16 69/M oesophagus carcinoma N/A multi-organ failure < 24 N/A C/T/L 17 78/F cholangio-carcinoma N/A multi-organ failure < 24 N/A T 18 75/M COPD, pneumonia N/A respiratory failure < 12 N/A C/T 19 59/F pleuritis carcinomatosa N/A respiratory failure < 24 N/A C/T/L 20 47/F pancreas carcinoma N/A abdominal bleeding < 24 N/A C/T/L 21 54/F gallbladder carcinoma N/A heart failure < 48 N/A C/T/L Abbreviations: C – cervical; COPD – chronic obstructive pulmonary disease; DD – disease duration; F – female; fALS – familial ALS; L – lumbar; M – male; PMD – postmortem delay; S – sacral; sALS – sporadic ALS; SPC – spinal cord; T – thoracic.
RkJQdWJsaXNoZXIy MTk4NDMw