110 Chapter 4 Table S3. Clinical details of MS and control cases Case Age/sex Diagnosis Disease duration, years Cause of death PMD, h:min MS cases 1 35/F SPMS 10 Euthanasia 10:20 2 54/F SPMS 27 Respiratory failure 9:25 3 50/F SPMS 18 Euthanasia 9:05 4 50/M SPMS 21 Unknown 10:50 5 63/F Unknown Unknown Unknown 10:50 Controls 1 84/M NNC N/A Heart failure 5:35 2 89/F NNC N/A Pneumonia 3:52 3 79/M NNC N/A Heart failure 6:20 4 73/F NNC N/A Mamma carcinoma 7:45 5 87/F NNC N/A Pneumonia 7:00 Abbreviations: F – female; M – male; N/A – not applicable; NNC – non-neurological control; PMD – postmortem delay; SPMS – secondary progressive multiple sclerosis. Table S4. Clinical history of mice with EAE Mouse number Sampling day (EAE score) Age (weeks) Acute young (aEAE) 1 14 (4) 10-15 2 12 (4) 10-15 3 15 (4.5) 10-15 4 15 (4) 10-15 5 13 (4.5) 10-15 6 20 (4.5) 10-15 Acute old (PEAE) 1 15 (4.5) > 50 2 13 (5) > 50 3 13 (4.5) > 50 4 16 (4.5) > 50 5 15 (5) > 50 6 17 (4.5) > 50 EAE mice were immunized with SCH in CFA and monitored (sampling day refers to the day of euthanasia after immunization). Indicated clinical scores are the maximal scores during neurological episodes of EAE. Abbreviations: CFA – complete Freund’s adjuvant; EAE – experimental autoimmune encephalomyelitis; aEAE – acute EAE, PEAE – progressive EAE; SCH – spinal cord homogenate. Table S5. Clinical history of marmosets Animal ID Sex Disease Status Age at EAE induction (years) Disease duration (days) Age (years) 1 M Control N/A N/A 3 4 F EAE 2.0 32 2.1 5 F EAE 1.6 105 1.9 8 F EAE 1.6 123 1.9 Abbreviations: EAE – experimental autoimmune encephalitis; F – female; M – male; N/A – not applicable.
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