Erik Nutma

135 TSPO expression in healthy and diseased brain 155. Chiang T, et al. Mouse model of middle cerebral artery occlusion. J Vis Exp. Feb 13 2011;(48) doi:10.3791/2761 156. Constantinescu CS, et al. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol. Oct 2011;164(4):1079-106. doi:10.1111/j.14765381.2011.01302.x 157. Torkildsen O, et al. The cuprizone model for demyelination. Acta Neurol Scand Suppl. 2008;188:72-6. doi:10.1111/j.16000404.2008.01036.x 158. James ML, et al. PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer’s disease using N-(2,5-dimethoxybenzyl)-2-18Ffluoro-N-(2-phenoxyphenyl)acetamide. J Nucl Med. Feb 2015;56(2):311-6. doi:10.2967/ jnumed.114.141648 159. Rapic S, et al. Imaging microglial activation and glucose consumption in a mouse model of Alzheimer’s disease. Neurobiol Aging. Jan 2013;34(1):351-4. doi:10.1016/j. neurobiolaging.2012.04.016 160. SerriereS,etal.Amyloidloadandtranslocatorprotein 18 kDa in APPswePS1-dE9 mice: a longitudinal study. Neurobiol Aging. Apr 2015;36(4):1639-52. doi:10.1016/j.neurobiolaging.2014.11.023 161. Tournier BB, et al. In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease. Cells. Aug 21 2020;9(9)doi:10.3390/cells9091941 162.Notter T, et al. Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia. Mol Psychiatry. Feb 2018;23(2):323-334. doi:10.1038/ mp.2016.248 163. Beckers L, et al. Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration. Mol Imaging Biol. Feb 2018;20(1):94-102. doi:10.1007/ s11307-017-1099-1 164.Owen DR, et al. Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans. J Cereb Blood Flow Metab. Aug 2017;37(8):2679-2690. doi:10.1177/0271678X17710182 165. Tong J, et al. Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies. J Cereb Blood Flow Metab. May 2020;40(5):1061-1076. doi:10.1177/0271678X19858003 166. YokokuraM, etal.Depictionofmicroglial activation in aging and dementia: Positron emission tomography with [(11)C]DPA713 versus [(11)C]( R)PK11195. J Cereb Blood Flow Metab. Mar 2017;37(3):877-889. doi:10.1177/0271678X16646788 167. Paul S, et al. Building a database for brain 18 kDa translocator protein imaged using [(11) C]PBR28 in healthy subjects. J Cereb Blood Flow Metab. Jun 2019;39(6):1138-1147. doi:10.1177/0271678X18771250 168. Cosenza-Nashat M, et al. Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol. Jun 2009;35(3):306-28. doi:10.1111/j.13652990.2008.01006.x 169.Werry EL, et al. Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders. Int J Mol Sci. Jun 28 2019;20(13)doi:10.3390/ijms20133161 170.Nutma E, et al. A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis. Brain. Oct 3 2019;doi:10.1093/ brain/awz287 171. Peferoen LA, et al. Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis. J Neuropathol Exp Neurol. Jan 2015;74(1):48-63. doi:10.1097/NEN.0000000000000149 172. Vogel DY, et al. Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J Neuroinflammation. Mar 4 2013;10:35. doi:10.1186/1742-2094-10-35 173. Zhang D, et al. Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol. Jun 2010;41(2-3):232-41. doi:10.1007/s12035-0108098-4 174.Guilarte TR. TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward. Pharmacol Ther. Sep 4 2018;doi:10.1016/j. pharmthera.2018.09.003 175.Gui Y, et al. Characterization of the 18 kDa translocator protein (TSPO) expression in postmortem normal and Alzheimer’s disease brains. Brain Pathol. Jul 5 2019;doi:10.1111/bpa.12763 176. Xu J, et al. Translocator protein in late stage Alzheimer’s disease and Dementiawith Lewy bodies brains. Ann Clin Transl Neurol. Aug 2019;6(8):14231434. doi:10.1002/acn3.50837 177. Iaccarino L, et al. An In Vivo (11)C-(R)-PK11195 PET and In Vitro Pathology Study of Microglia Activation in Creutzfeldt-Jakob Disease. Mol Neurobiol. Apr 2018;55(4):2856-2868. doi:10.1007/s12035-0170522-6 178. Holmes SE, et al. Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study. Biol Psychiatry. Jan 1 2018;83(1):61-69. doi:10.1016/j. biopsych.2017.08.005 179. Setiawan E, et al. Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study. Lancet Psychiatry. Apr 2018;5(4):339-347. doi:10.1016/S2215-0366(18)30048-8

RkJQdWJsaXNoZXIy MTk4NDMw