193 White matter microglia heterogeneity 1. Thomas WE. Characterization of the dynamic nature of microglial cells. Brain Res Bull. Aug 1990;25(2):351-4. doi:10.1016/03619230(90)90083-c 2. Yin J, et al. The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer. J Immunol Res. 2017/12/19 2017;2017:5150678. doi:10.1155/2017/5150678 3. Ginhoux F, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. Nov 5 2010;330(6005):841-5. doi:10.1126/ science.1194637 4. Tay TL, et al. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci. Jun 2017;20(6):793-803. doi:10.1038/nn.4547 5. Askew K, et al. Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. Cell Rep. Jan 10 2017;18(2):391-405. doi:10.1016/j.celrep.2016.12.041 6. Gosselin D, et al. An environment-dependent transcriptional network specifies human microglia identity. Science. Jun 23 2017;356(6344):eaal3222. doi:10.1126/science.aal3222 7. Tada M, et al. Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids. Ann Neurol. Oct 2016;80(4):554-65. doi:10.1002/ana.24754 8. Chen JF, et al. Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease. Neuron. Jul 21 2021;109(14):2292-2307 e5. doi:10.1016/j. neuron.2021.05.012 9. McKenzie IA, et al. Motor skill learning requires active central myelination. Science. Oct 17 2014;346(6207):318-22. doi:10.1126/ science.1254960 10. Steadman PE, et al. Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice. Neuron. Jan 8 2020;105(1):150-164 e6. doi:10.1016/j.neuron.2019.10.013 11. Wang F, et al. Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory. Nat Neurosci. Apr 2020;23(4):481-486. doi:10.1038/s41593-020-0588-8 12. Xiao L, et al. Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nat Neurosci. Sep 2016;19(9):1210-1217. doi:10.1038/nn.4351 13. Colton CA. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol. Dec 2009;4(4):399-418. doi:10.1007/s11481-009-9164-4 14. Wynn TA, et al. Macrophage biology in development, homeostasis and disease. Nature. Apr 25 2013;496(7446):445-55. doi:10.1038/ nature12034 15. Vogel DY, et al. Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J Neuroinflammation. Mar 4 2013;10:35. doi:10.1186/1742-2094-10-35 16. Kim CC, et al. Brain trauma elicits non-canonical macrophage activation states. J Neuroinflammation. May 24 2016;13(1):117. doi:10.1186/s12974-0160581-z 17. Ransohoff RM. A polarizing question: do M1 and M2 microglia exist? Nat Neurosci. Jul 26 2016;19(8):987-91. doi:10.1038/nn.4338 18. Zrzavy T, et al. Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis. Brain. Jul 1 2017;140(7):1900-1913. doi:10.1093/brain/awx113 19. Bottcher C, et al. Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat Neurosci. Jan 2019;22(1):78-90. doi:10.1038/ s41593-018-0290-2 20. Jurga AM, et al. Overview of General and Discriminating Markers of Differential Microglia Phenotypes. Review. Front Cell Neurosci. 2020-August-06 2020;14(198):198. doi:10.3389/ fncel.2020.00198 21. Amici SA, et al. Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia. Review. Front Immunol. 2017-November-10 2017;8(1520):1520. doi:10.3389/ fimmu.2017.01520 22. Jordao MJC, et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. Jan 25 2019;363(6425):eaat7554. doi:10.1126/science. aat7554 23. Mrdjen D, et al. High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease. Immunity. Feb 20 2018;48(2):380-395 e6. doi:10.1016/j.immuni.2018.01.011 24. Van Hove H, et al. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nat Neurosci. Jun 2019;22(6):10211035. doi:10.1038/s41593-019-0393-4 25. Martin E, et al. Analysis of Microglia and Monocytederived Macrophages from the Central Nervous System by Flow Cytometry. J Vis Exp. Jun 22 2017;2017(124):1-7. doi:10.3791/55781 26. Kierdorf K, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8dependent pathways. Nat Neurosci. Mar 2013;16(3):273-80. doi:10.1038/nn.3318 27. Schulz C, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. Apr 6 2012;336(6077):86-90. doi:10.1126/ science.1219179 References
RkJQdWJsaXNoZXIy MTk4NDMw