Erik Nutma

194 Chapter 8 28. Bennett ML, et al. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A. Mar 22 2016;113(12):E1738-46. doi:10.1073/ pnas.1525528113 29. Butovsky O, et al. Identification of a unique TGFbeta-dependent molecular and functional signature in microglia. Nat Neurosci. Jan 2014;17(1):131-43. doi:10.1038/nn.3599 30. Keren-Shaul H, et al. A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease. Cell. Jun 15 2017;169(7):12761290 e17. doi:10.1016/j.cell.2017.05.018 31. Masuda T, et al. Novel Hexb-based tools for studying microglia in the CNS. Nat Immunol. Jul 2020;21(7):802-815. doi:10.1038/s41590-0200707-4 32. Baker D, et al. Mouse models of multiple sclerosis: lost in translation? Curr Pharm Des. 2015;21(18):2440-52. doi:10.2174/138161282166 6150316122706 33. Dawson TM, et al. Animal models of neurodegenerative diseases. Nat Neurosci. 2018/10/01 2018;21(10):1370-1379. doi:10.1038/ s41593-018-0236-8 34. White GE, et al. Fractalkine: a survivor’s guide: chemokines as antiapoptotic mediators. Arterioscler Thromb Vasc Biol. Mar 2012;32(3):58994. doi:10.1161/ATVBAHA.111.237412 35. Harrison JK, et al. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A. Sep 1 1998;95(18):10896-901. doi:10.1073/pnas.95.18.10896 36. Garcia JA, et al. Analyses of microglia effector function using CX3CR1-GFP knock-in mice. Methods Mol Biol. 2013;1041(4):307-17. doi:10.1007/9781-62703-520-0_27 37. Jung S, et al. Analysis of fractalkine receptor CX(3) CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. Jun 2000;20(11):4106-14. doi:10.1128/ MCB.20.11.4106-4114.2000 38. Goldmann T, et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci. Nov 2013;16(11):1618-26. doi:10.1038/nn.3531 39. Yona S, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages underhomeostasis. Immunity. Jan242013;38(1):7991. doi:10.1016/j.immuni.2012.12.001 40. Kaiser T, et al. Tmem119-EGFP and Tmem119CreERT2 Transgenic Mice for Labeling and Manipulating Microglia. eNeuro. Jul/Aug 2019;6(4) doi:10.1523/ENEURO.0448-18.2019 41. McKinsey GL, et al. A new genetic strategy for targeting microglia in development and disease. Elife. Jun 23 2020;9:e54590. doi:10.7554/ eLife.54590 42. Dubbelaar ML, et al. The Kaleidoscope of Microglial Phenotypes. Review. Front Immunol. 2018-July-31 2018;9(1753):1753. doi:10.3389/ fimmu.2018.01753 43. Ajami B, et al. Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models. Nat Neurosci. Apr 2018;21(4):541-551. doi:10.1038/s41593-018-0100-x 44. Svensson V, et al. Power Analysis of Single Cell RNA-Sequencing Experiments Europe PMC Funders Group. Nat Methods. 2017;14(4):381-387. doi:10.1038/nmeth.4220.Power 45. See P, et al. A Single-Cell Sequencing Guide for Immunologists. Front Immunol. 2018;9(OCT):2425. doi:10.3389/fimmu.2018.02425 46. Li Q, et al. Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron. Jan 16 2019;101(2):207-223 e10. doi:10.1016/j. neuron.2018.12.006 47. Matcovitch-Natan O, et al. Microglia development follows a stepwise program to regulate brain homeostasis. Science. Aug 19 2016;353(6301):aad8670. doi:10.1126/science. aad8670 48. Stahl PL, et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science. Jul 1 2016;353(6294):7882. doi:10.1126/science.aaf2403 49. Chen WT, et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease. Cell. Aug 20 2020;182(4):976-991 e19. doi:10.1016/j. cell.2020.06.038 50. Hasel P, et al. Neuroinflammatory astrocyte subtypes in the mouse brain. Nat Neurosci. Oct 2021;24(10):1475-1487. doi:10.1038/s41593-02100905-6 51. De Biase LM, et al. Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues. Neuroscientist. Aug 2019;25(4):314-333. doi:10.1177/1073858418800996 52. von Bartheld CS, et al. The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. J Comp Neurol. Dec 15 2016;524(18):3865-3895. doi:10.1002/ cne.24040 53. Lawson LJ, et al. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience. 1990;39(1):151-70. doi:10.1016/0306-4522(90)90229-w 54. Grabert K, et al. Microglial brain region-dependent diversity and selective regional sensitivities to aging. Nat Neurosci. Mar 2016;19(3):504-16. doi:10.1038/nn.4222 55. Yamasaki R, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med. Jul 28 2014;211(8):1533-49. doi:10.1084/jem.20132477 56. Cronk JC, et al. Peripherally derived macrophages

RkJQdWJsaXNoZXIy MTk4NDMw