209 General Discussion 1. Trias E, et al. Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS. JCI Insight. Oct 4 2018;3(19)doi:10.1172/jci. insight.123249 2. Guilarte TR. TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward. Pharmacol Ther. Feb 2019;194:44-58. doi:10.1016/j.pharmthera.2018.09.003 3. Kreisl WC, et al. PET imaging of neuroinflammation in neurological disorders. Lancet Neurol. Nov 2020;19(11):940-950. doi:10.1016/S14744422(20)30346-X 4. Chew S, et al. Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis. Mini Review. Front Neurol. 2019-March-01 2019;10(135):135. doi:10.3389/ fneur.2019.00135 5. Arlicot N, et al. Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation. Eur J Nucl Med Mol Imaging. Dec 2008;35(12):2203-11. doi:10.1007/ s00259-008-0834-x 6. Dickens AM, et al. Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180. J Nucl Med. Mar 2014;55(3):466-72. doi:10.2967/ jnumed.113.125625 7. Domene A, et al. Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer’s Disease versus Age-Matched Controls: A Presymptomatic Stage Study. Int J Alzheimers Dis. 2016;2016:5696241. doi:10.1155/2016/5696241 8. Israel I, et al. Combined [(18)F]DPA-714 micropositron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice. journal article. J Neuroinflammation. Jun 7 2016;13(1):140. doi:10.1186/s12974-0160604-9 9. Ji B, et al. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses inmouse models of Alzheimer’s and other CNS pathologies. J Neurosci. Nov 19 2008;28(47):12255-67. doi:10.1523/ JNEUROSCI.2312-08.2008 10. Lavisse S, et al. Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. J Neurosci. Aug 8 2012;32(32):10809-18. doi:10.1523/ JNEUROSCI.1487-12.2012 11. Lavisse S, et al. [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain. Eur J Nucl Med Mol Imaging. Mar 2015;42(3):478-94. doi:10.1007/s00259-0142962-9 12. Maeda J, et al. Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res. Jul 9 2007;1157:100-11. doi:10.1016/j.brainres.2007.04.054 13. Mattner F, et al. Evaluation of [(1)(2)(3)I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation. Eur J Nucl Med Mol Imaging. Aug 2011;38(8):1516-28. doi:10.1007/s00259-0111784-2 14. Nguyen DL, et al. Longitudinal positron emission tomography imaging of glial cell activation in a mouse model of mesial temporal lobe epilepsy: Toward identification of optimal treatment windows. Epilepsia. Jun 2018;59(6):1234-1244. doi:10.1111/epi.14083 15. Rojas S, et al. Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats. J Cereb Blood Flow Metab. Dec 2007;27(12):1975-86. doi:10.1038/ sj.jcbfm.9600500 16. Serriere S, et al. Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study. Neurobiol Aging. Apr 2015;36(4):1639-1652. doi:10.1016/j. neurobiolaging.2014.11.023 17. Wang Y, et al. PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714. Eur J Nucl Med Mol Imaging. Jul 2014;41(7):1440-9. doi:10.1007/s00259-0142727-5 18. Daugherty DJ, et al. A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med. Jun 2013;5(6):891-903. doi:10.1002/ emmm.201202124 19. Cosenza-Nashat M, et al. Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol. Jun 2009;35(3):306-28. doi:10.1111/j.13652990.2008.01006.x 20. Liu B, et al. In Vivo Detection of Age- and DiseaseRelated Increases in Neuroinflammation by 18FGE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer’s Transgenic Mice. J Neurosci. Nov 25 2015;35(47):15716-30. doi:10.1523/ JNEUROSCI.0996-15.2015 21. Maeda J, et al. In vivo positron emission tomographic imaging of glial responses to amyloidbeta and tau pathologies in mouse models of Alzheimer’s disease and related disorders. J Neurosci. Mar 23 2011;31(12):4720-30. doi:10.1523/JNEUROSCI.3076-10.2011 22. Owen DR, et al. Pro-inflammatory activation of primary microglia and macrophages increases References
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