93 TSPO in neurodegeneration 8 Weeks 20 Weeks 0 50 100 150 200 250 TSPO+GFAP+ cells / mm2 8 Weeks 20 Weeks 0 50 100 150 200 250 TSPO+IBA1+ cells / mm2 TSPO/IBA1 TSPO/GFAP TSPO/GFAP TSPO/IBA1 a AppNL-G-F TAUP301S b c d e f g h i j k l m n o p 10 Weeks 28 Weeks 0 100 200 300 400 TSPO+ cells / mm2 ✱✱✱✱ 8 Weeks 20 Weeks 0 50 100 150 200 250 GFAP+ cells / mm2 8 Weeks 20 Weeks 0 50 100 150 200 250 IBA1+ cells / mm2 8 Weeks 20 Weeks 0 50 100 150 200 250 TSPO+ cells / mm2 CON TAU CON TAU 0 10 20 30 TSPO+ μm2/ cell ✱ microglia astrocytes CON APP CON APP 0 10 20 30 TSPO+ μm2/ cell ✱✱✱✱ microglia astrocytes WT APPNLGF WT TAUP301S 10 Weeks 28 Weeks 0 100 200 300 400 GFAP+ cells / mm2 10 Weeks 28 Weeks 0 100 200 300 400 IBA1+ cells / mm2 ✱✱ 10 Weeks 28 Weeks 0 100 200 300 400 TSPO+GFAP+ cells / mm2 ✱✱ 10 Weeks 28 Weeks 0 100 200 300 400 TSPO+IBA1+ cells / mm2 ✱✱✱✱
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