51 Bronchopulmonary dysplasia, IGF-I & nutrition 3 as at least 60% of enteral intake consisting of respectively donor human milk or formula. Table 1. Reference values used for the nutritional composition of human milk per 100 ml OMM OMM + BMF (4.4g/100ml) DHM DHM + BMF (4.4g/100ml) Energy (kcal) 68.5 83.8 60 75 Protein (g) 1.5 2.6 0.8 1.9 Carbohydrates (g) 7.3 10.0 7.5 10.2 Fat (g) 3.3 3.3 2.9 2.9 BMF: Breast milk fortifier, DHM: donor human milk, OMM: own mother’s milk Reference values for OMM were derived from meta-analyses.32 33 Donor human milk composition was based on analyses of the donor milk batches administered to the first 23 study participants. Statistical analysis Comparisons between infants with and without BPDwere analyzed, depending on the data distribution, with either the independent sample T-test or Mann-Whitney U test and the Chi-square test or the Fisher-Exact test. Logistic regression was used to correct hypothesized predictors and potential confounders for gestational age. A final prediction model was designed which included every factor which was significantly associated with BPD after correction for gestational age. A backward regression analysis was used to design this prediction model. Amixedmodel with a random intercept and slope, IGF-I (µgram/L) as the dependent variable and postmenstrual age (weeks) as a covariate was used to estimate the mean change of IGF-I in µgram/L/week per infant. The same was done for IGFBP-3 levels. Analyses were conducted using IBM® SPSS® Statistics 22 for Windows (IBM Corp., Armonk, NY). Two-sided statistical significance was assumed at p-values less than 0.05. Results Eighty-six infants were included in the analyses. 14 (table 2) Twenty-nine infants were classified as having BPD: 14 infants had grade 1 BPD, 15 infants had grade 2 BPD and there were no cases of grade 3 BPD.
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