53 Bronchopulmonary dysplasia, IGF-I & nutrition 3 Infants who developed BPD, had a lower gestational age and accordingly a lower birth weight, as well as a longer duration of mechanical ventilation and a higher incidence of comorbidities. (Table 2) However, after correction for gestational age, IRDS remained the only comorbidity significantly associated with the occurrence of BPD: OR 4.2 (95% CI 1.4 – 13.0, p = 0.012). In infants who developed BPD the mean change in IGF-I was 2.8 + 2.2 µgram/L per week from birth through to 34 weeks PMA versus 4.5 + 1.8 µgram/L per week in infants without BPD. (Figure 1) Between birth and 34 weeks PMA every µgram/L per week increase in IGF-I lowered the odds of BDP 0.68 times (95% CI 0.48 − 0.96, p = 0.026; corrected for gestational age). The change in IGF-I between birth and 36 weeks PMA was not significantly different between infants with and without BPD. (Figure 1) Figure 1. Mean change in IGF-I and IGFBP-3 serum levels in infants with and without BPD up to 36 weeks postmenstrual age The mean change in IGF-I and IGFBP-3 was estimated for every individual using a mixed model.
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