55 Bronchopulmonary dysplasia, IGF-I & nutrition 3 duration of predominant donor human milk feeding was 4 days (IQR 0 – 11.5) in infants who did not develop BPD compared to 7 days (2.5 – 18.5) in infants who developed BPD (not significant after correction for gestational age). Throughout hospitalization 13 infants were predominantly fed donor human milk for at least a week. Of these infants 10 (76.9%) developed BPD compared to 19 out of 73 (26%) of infants who were predominantly fed donor milk for a shorter period (p 0.001). Corrected for gestational age, being predominantly fed donor milk for at least one week increased the odds of BPD by 4.6 (95% CI 1.03 - 20.55, p = 0.046) compared to infants fed donor milk for less than a week. Figure 3. Enteral intake in preterm infants with and without BPD during hospitalization After correction for gestational age there were no significant differences the type of enteral nutrition in infants with or without BPD. Median duration of parenteral nutrition was 12 days (IQR 9 – 22) in infants who developed BPD compared to 10 days (IQR 8 – 13) in infants who did not develop BPD (not significant after correction for gestational age). In the first two weeks of life infants who developed BPD had a larger proportion of their intake as parenteral nutrition compared to infants who did not develop BPD: 37.9 % (95% CI 29.4 – 49.5) versus 32.3% (95% CI 23.2 – 42.7), (not significant after correction for gestational age). The change in IGF-I in μgram/L per week, gestational age in weeks, IRDS (yes or no) and predominant donor human milk use for at least one week compared to less than a week were included in our final predictive model. A slow increase in IGF-I, lower gestational age and at least one week of predominant donor human milk feeding compared to less than a week of predominant donor human milk feeding increased the odds of BPD. (table 3) The macronutrient and caloric intake did significantly impact this association. (see web appendices)
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