TABLE OF CONTENTS INTRODUCTION 11 CHAPTER 1: General introduction 13 Background 14 The regulation of fetal and postnatal growth and body composition 14 Aims and objectives 16 Study design 17 Thesis outline 20 References 21 PART I. THE ROLE OF NUTRITION AND IGF-I ON GROWTH, BODY COMPOSITION AND HEALTH OUTCOMES IN PRETERM INFANTS IN INFANCY 25 CHAPTER 2: Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition and neurodevelopment 27 Abstract 28 Introduction 29 IGF I regulation 30 The role of IGF I in growth and body composition 30 The role of IGF I in neurodevelopment 34 The role of dietary proteins in growth and body composition 35 The role of dietary proteins in neurodevelopment 37 IGF I and dietary proteins 38 Conclusions 39 References 40 CHAPTER 3: Associations between bronchopulmonary dysplasia, Insulin-like growth factor I and nutrition 47 Abstract 48 Introduction 49 Methods 49 Results 51 Discussion 56 Conclusions 58 References 59 Supplemental material 61
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