66 Chapter 3 Association between donor human milk, caloric intake and BPD B (SE) p-value Odds ratio (95% CI) Included variables Constant -5.9 (3.8) 0.003 Predominant donor human milk for at least 1 weeka 2.5 (0.8) 0.001 12.2 (2.7 – 54.4) Caloric intake (kcal/kg/day) 0.0 (0.0) 0.198 1.0 (1.0 – 1.1) R² = 0.137 (Cox & Snell), 0.190 (Nagelkerke). Model χ² (2) = 12.659, p 0.002 a Predominant donor human milk for at least one week compared to less than one week predominant donor human milk feeding. Predominant donor milk feeding was defined as at least 60% of total enteral intake consisting of donor human milk. Multivariable logistic regression for the occurrence of BPD including nutrient intake B (SE) p-value Odds ratio (95% CI) Included variables Constant 37.9 (13.9) 0.006 Change in IGF-I (µgram/L per week) -0.4 (0.2) 0.040 0.67 (0.45 – 0.98) Gestational age at birth (weeks) -1.0 (0.4) 0.006 0.38 (0.19 – 0.76) Predominant donor human milk for at least 1 weeka 2.7 (1.1) 0.014 15.3 (1.72 – 136.53) IRDS 1.5 (0.9) 0.111 4.47 (0.71-28.16) Mean fat intake (g/kg/day) -2.3 (1.2) 0.066 0.10 (0.01 – 1.16) R² = 0.428 (Cox & Snell), 0.595 (Nagelkerke). Model χ² (5) = 33.53, p < 0.001 a Predominant donor human milk for at least one week compared to less than one week predominant donor human milk feeding. Predominant donor milk feeding was defined as at least 60% of total enteral intake consisting of donor human milk. When caloric, protein and carbohydrate intake were included in the model, the terms for the nutrient intake and IRDS were removed in the backward regression, resulting in the same regression model as depicted in table 3 of the manuscript.
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