170 Figure 4. Acquisition of nocebo responses. Mean Numeric Rating Scale (NRS) pain ratings (sd) are depicted across all three groups (N = 72) for the first nocebo and the first control trial of extinction phase. Residual nocebo responses We analyzed whether the magnitude of nocebo hyperalgesia at the end of extinction differed between groups. Figure 5b illustrates the differences in pain ratings for the last nocebo trial and the last control trial of the extinction phase, across all groups. High-pain group The analysis showed a significant interaction between group and trial type, with nocebo responses at the end of extinction (nocebo vs control Acquisition Nocebo Control NRS pain rating 8 7 6 5 4 3 2 1 0 Contol High-pain High-fear Group
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