184 Overall, this study implemented a novel, clinically relevant learning model that investigated the effects of fear inductions on nocebo. The findings provided evidence that experienced threat in the form of higher pain stimulations led to significantly larger nocebo hyperalgesia, compared to lower pain. Importantly, this effect was mediated by selfreported fear. The anticipation of threat, however, did not impact nocebo magnitudes. This study also indicated that higher pain stimulations induce amplified nocebo responses that persist after a period of extinction. Given the substantial impact of higher pain and pain-related fear on nocebo hyperalgesia, further assessment of these variables in relation to pain aggravation and chronification may be of value.
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