230 were then exposed to the baseline pain stimulations. Participants then underwent the nocebo acquisition and extinction procedures. After the end of the experiment, participants completed the second WMS–IV, were asked to answer the exit questions, and then were debriefed. Figure 1. Timeline of the experimental procedure of this study. After screening for inclusion and pain calibrations, participants underwent a pre-conditioning phase. After the first learning task, D-cycloserine (DCS) or placebo was administered, and the psychological questionnaires were completed. In the fMRI part, participants completed structural scans and thereafter a first functional scan while receiving baseline moderate and high pain stimuli. Thereafter, three scans covered the acquisition and extinction of nocebo hyperalgesia. Finally, the second learning task, exit questionnaire, and a debriefing were completed. Statistical analysis Data screening and behavioral measures Analyses of demographic, psychological, and behavioral measures were performed for descriptive purposes and as manipulation checks.
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