280 effects and the factors that characterize biobehavioral aspects of pain processing. We carried out systematic and comprehensive reviews and a meta-analysis of existing studies, as well as a series of experimental studies utilizing a resourceful mixture of classic and innovative biobehavioral methods, including classical conditioning, EMG, EEG, and fMRI. Our findings emerging from this work support the understanding of learning as an intricate, multifaceted, and powerful process, able to detrimentally influence sensory perception, altering the way in which individuals perceive pain. Our knowledge from nocebo research highlights the vast variability of sensory perception and conscious experience in humans. The results of the present PhD project further support the notion that negative inputs from the environment become encoded in our plastic brains, producing measurable adverse effects on pain. If we are to utilize research to improve pain management and outcomes, there is a pressing need for scientific research to translate this growing understanding of learned pain responses beyond the laboratory and into clinical practice.
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