Chapter 3 – Comprehensive review 71 Kong 2008 13 Conditioning with NVS Thermal 6 trials in conditioning 2 trials in evocation (7-second plateau) fMRI Differences in BOLD activations and connectivity analyses Decreased activations in dorsolateral prefrontal cortex and orbitofrontal cortex. Increased activations in mid temporal gyrus, insula, anterior cingulate, hippocampus Kong 2013 46 Conditioning Thermal 4 trials in conditioning 3 trials in evocation (12-second plateau) fMRI Differences in BOLD activations Functional connectivity between frontoparieta l regions and rostral anterior cingulate /medial prefrontal cortex was associated with nocebo Rodrigu ezRaecke 2010 38 NVS Thermal n/a fMRI Differences in BOLD activations Increased activation of operculum. Ellerbro ck 2015 20 NVS Thermal n/a fMRI Differences in BOLD activations and connectivity analyses Increased activation of the operculum. Deactivation of the periaqueduct al grey. Freeman 2015 24 Conditioning with NVS Thermal 3 trials in conditioning 1 trial in evocation (7-second plateau) fMRI Differences in BOLD activations Increased activations in insula, orbitofrontal cortex, and periaqueduct al grey Jensen 2015 24 Conditioning & Nonconscious evocation Thermal 25 trials in conditioning (4-second plateau) fMRI Differences in BOLD activations Increased activations in insula, anterior cingulate cortex, thalamus, brainstem, amygdala, /hippoc. Egorova 2020 Conditioning with NVS Thermal 3 trials in conditioning 1 trial in evocation (7-second plateau) fMRI Differences in BOLD activations and connectivity analyses Increased amygdala- striatum connectivity correlated with magnitude of nocebo responses.
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