107 Evaluation of clarity of the STOPP/START criteria - SI Table SI1.7. START - Clarity rating of conditions, from lowest to highest ranking. START Condition Clarity rating n=34 A2 in the presence of chronic atrial fibrillation, where Vitamin K antagonists or direct thrombin inhibitors or factor Xa inhibitors are contraindicated. 33% C2 in the presence of persistent major depressive symptoms. 33% C6 for Restless Legs Syndrome, once iron deficiency and severe renal failure have been excluded. 33% E2 in patients taking long-term systemic corticosteroid therapy. 33% E7 in patients taking methotexate. 33% A5 with a documented history of coronary, cerebral or peripheral vascular disease, unless the patient’s status is end-of-life or age is > 85 years. 42% C3 for mild-moderate Alzheimer’s dementia or Lewy Body dementia (rivastigmine). 42% E1 with active, disabling rheumatoid disease. 42% A1 in the presence of chronic atrial fibrillation. 50% B1 for mild to moderate asthma or COPD. 50% B2 for moderate-severe asthma or COPD, where FEV1 <50% of predicted value and repeated exacerbations requiring treatment with oral corticosteroids. 50% C1 in idiopathic Parkinson’s disease with functional impairment and resultant disability. 50% C5 for persistent severe anxiety that interferes with independent functioning. 50% D1 with severe gastro-oesophageal reflux disease or peptic stricture requiring dilatation. 50% E5 in older people who are housebound or experiencing falls or with osteopenia (Bone Mineral Density T-score is > -1.0 but < -2.5 in multiple sites). 50% E6 with a history of recurrent episodes of gout. 50% G1 with symptomatic prostatism, where prostatectomy is not considered necessary. 50% G2 with symptomatic prostatism, where prostatectomy is not considered necessary. 50% H1 in moderate-severe pain, where paracetamol, NSAIDs or lowpotency opioids are not appropriate to the pain severity or have been ineffective. 50% A3 with a documented history of coronary, cerebral or peripheral vascular disease. 58% A6 with systolic heart failure and/or documented coronary artery disease. 58% D2 for diverticulosis with a history of constipation. 58% 2
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