236 CHAPTER 3.2 Table 4. Clinical outcomes. Events (%) Outcome Control (N=1,045) Intervention (N=963) HR (95% CI) 1 P value First drug-related hospital admission 234 (22.4%) 211 (21.9%) 0.95 (0.77 to 1.17) 0.62 Death 203 (19.4%) 172 (17.9%) 0.90 (0.71 to 1.13) 0.37 Death from cancer 55 (5.3%) 43 (4.5%) 0.76 (0.47 to 1.23) 0.27 First hospitalization 516 (49.4%) 447 (46.4%) 0.87 (0.75 to 1.02) 0.08 First fall 263 (25.2%) 237 (24.6%) 0.96 (0.79 to 1.15) 0.64 First preventable drug-related hospital admission 2 100 (9.6%) 84 (8.7%) 0.89 (0.63 to 1.25) 0.49 First drug-related hospital admission in patients with ≥1 STOPP recommendation implemented 2,3 156 (17.8%) 64 (16.1%) 0.88 (0.65 to 1.19) 0.41 OR (95% CI) 1 In hospital death within 2 months 54 (5.2%) 41 (4.3%) 0.81 (0.51 to 1.29) 0.38 1 HR <1 and OR <1 indicate less events in the intervention group; 2 Post hoc analysis; 3 For drug-related hospital admissions occurring after 2 months from enrolment (N=398 in the intervention group, N=875 in the control group still in the trial after 2 months with available STRIPA data). Note that this analysis of a subset of intervention patients may be biased from unequal distribution of confounding factors and should be regarded as exploratory. For time-to-event outcomes, between-group differences were first analysed using a randomeffects Cox proportional hazards model; for the first drug-related hospital admission, first hospitalization, first fall, first preventable drug-related hospital admission, and death by cancer, we then used an extension of the Fine-Gray proportional model to account for the competing risk of death (results are presented in the appendix). Drug-related hospital admission was considered preventable when deemed by the adjudication committee as potentially related to a drug overuse, underuse or misuse (i.e. drug with an indication, but error in prescribing, dispensing, administering or monitoring the drug). Abbreviations: CI, confidence interval; HR, hazard ratio; N, number; OR, odds ratio .
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