237 OPERAM: cluster randomised controlled trial Table 5. Medication-related and patient-reported outcomes. Outcome Follow-up (month) Control Intervention P value Medication-related outcomes N 1 Events (%) N 1 Events (%) OR (95% CI) 2 Clinically significant drug-drug interaction 2 893 521 (58.3%) 832 462 (55.5%) 0.87 (0.67 to 1.14) 0.31 Drug misuse 3 2 893 378 (42.3%) 832 355 (42.7%) 0.99 (0.81 to 1.20) 0.92 Drug overuse 3 2 893 376 (42.1%) 832 348 (41.8%) 0.99 (0.82 to 1.20) 0.91 Drug underuse 3 2 893 638 (71.4%) 832 583 (70.1%) 0.91 (0.70 to 1.17) 0.45 N 1 Mean (SD) N 1 Mean (SD) Adjusted difference (95% CI) 4 Number of long-term medications 5 2 893 11.0 (4.27) 833 11.2 (4.54) -0.13 (-0.49 to 0.22) 0.47 6 824 11.5 (4.81) 777 11.9 (5.04) -0.10 (-0.46 to 0.26) 0.60 12 767 10.7 (4.57) 726 10.7 (4.54) -0.20 (-0.56 to 0.17) 0.29 Patient-reported outcomes N 1 Mean (SD) N 1 Mean (SD) Adjusted difference (95% CI) 4 QoL/EQ-VAS 6 2 828 64.0 (20.1) 764 65.0 (19.4) 0.63 (-1.24 to 2.50) 0.51 6 763 65.6 (18.8) 727 67.1 (17.0) 1.34 (-0.58 to 3.25) 0.17 12 703 65.1 (19.1) 657 67.1 (17.8) 2.29 (0.31 to 4.26) 0.02 Pain/discomfort score 7 2 850 1.16 (1.20) 787 1.09 (1.12) -0.04 (-0.16 to 0.07) 0.43 6 777 1.17 (1.18) 741 1.08 (1.16) -0.07 (-0.19 to 0.04) 0.20 12 722 1.15 (1.20) 673 1.02 (1.11) -0.11 (-0.23 to 0.01) 0.06 3
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