245 OPERAM: cluster randomised controlled trial pharmaceutical and medical device companies provide direct funding to some of these studies or an up-to-date list of CTU Bern’s conflicts of interest see https:// www.ctu.unibe.ch/research/declaration_of_interest/index_eng.html. DOM has a patent A Prescription Decision Support System (based on screening tool of older person’s prescriptions and screening tool to alert to the right treatment (STOPP/ START) prescribing rules) issued to European Patent Office (Munich). MS reports a 2011 grant and personal fees from Spru IT, before the conduct of the study; in addition, MS reports a settlement agreement between Spru IT and Utrecht University, in which all systematic tool to reduce inappropriate prescribing (STRIP) assistant IP is transferred to Utrecht University, in exchange for obtaining a free but non-exclusive right to provide STRIP assistant consultancy or support services, or both on a commercial basis, and to update the STRIP assistant, until June 2023. The lead author (NR) affirms that themanuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as originally planned (and, if relevant, registered) have been explained. Data availability statement Data for this study will be made available to others in the scientific community upon request after publication. Data will be made available for scientific purposes for researchers whose proposed use of the data has been approved by a publication committee. Data and documentation will be made available through a secure file exchange platform after approval of proposal and a data transfer agreement is signed (which defines obligations that the data requester must adhere to with regard to privacy and data handling). Partially deidentified participant data limited to the data used for this work will be made available, along with a data dictionary and annotated case report forms. For data access, please contact the corresponding author. Dissemination to participants and related patient and public communities The results of the Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Patients (OPERAM) trial are published in a peer reviewed journal. In addition, we will disseminate results at local meetings in each country, through lay press and media releases and newsletters to the trial participants, as well as through the World Health Organisation Patients for Patient Safety (PFPS) Advocate Group (Margaret Murphy, member of the OPERAM advisory board). 3
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