260 CHAPTER 3.2 Table SI1.3. Per protocol analysis for time to first event outcomes. Events (%) Outcome Control Intervention HR (95% CI) 1 P value Regression on cause-specific hazards First drug-related hospital admission 156/871 (17.9%) 93/556 (16.7%) 0.91 (0.69 to 1.19) 0.49 Death by cancer 37/943 (3.9%) 21/599 (3.5%) 0.87 (0.46 to 1.64) 0.66 First hospitalization 308/751 (41.0%) 182/491 (37.1%) 0.85 (0.70 to 1.04) 0.11 First fall 177/861 (20.6%) 115/548 (21.0%) 1.03 (0.81 to 1.31) 0.80 Death 125/943 (13.3%) 67/599 (11.2%) 0.85 (0.61 to 1.17) 0.32 First preventable drug-related hospital admission 2 65/871 (7.5%) 38/556 (6.8%) 0.89 (0.58 to 1.37) 0.60 Regression on sub hazards (taking into account the competing risk of death) First drug-related hospital admission 156/871 (17.9%) 93/556 (16.7%) 0.91 (0.70 to 1.19) 0.51 Death by cancer 37/943 (3.9%) 21/599 (3.5%) 0.87 (0.46 to 1.65) 0.66 First hospitalization 308/751 (41.0%) 182/491 (37.1%) 0.85 (0.70 to 1.04) 0.11 First fall 177/861 (20.6%) 115/548 (21.0%) 1.03 (0.81 to 1.31) 0.79 First preventable drug-related hospital admission2 65/871 (7.5%) 38/556 (6.8%) 0.90 (0.59 to 1.37) 0.62 1 HR<1 indicates fewer events in the intervention group; 2 Post hoc analysis.drug-related hospital admission was considered preventable when deemed by the adjudication committee as potentially related to a drug overuse, underuse or misuse (i.e. drug with an indication, but error in prescribing, dispensing, administering or monitoring the medication). Abbreviations: CI, confidence interval; HR, hazard ratio
RkJQdWJsaXNoZXIy MTk4NDMw