288 CHAPTER 4.1 Table 2. Continued. Top 10 most frequently generated STOPP signals Frequency, N Acceptance, % STOPP E5 – Colchicine if eGFR < 10 ml/min/1.73m2 0 N/A STOPP F1 – Prochlorperazine or metoclopramide with Parkinsonism 0 N/A STOPP G1 – Theophylline as monotherapy for COPD 0 N/A STOPP H1 – NSAID other than COX-2 selective agents with history of peptic ulcer disease or gastrointestinal bleeding, unless with concurrent PPI or H2 antagonist 0 N/A STOPP J2 – Thiazolidenediones in patients with heart failure 0 N/A STOPP J4 – Oestrogens with a history of breast cancer or venous thromboembolism 0 N/A STOPP M1 – Concomitant use of two or more drugs with antimuscarinic/anticholinergic properties 0 N/A Total 3465 40.1% Top 10 most frequently generated START signals Frequency, N Acceptance, % START H1 – High potency opioids in moderatesevere pain, where paracetamol, NSAIDs or lowpotency opioids are not appropriate to the pain severity or have been ineffective. 162 2.5% START A6 – ACE-I with systolic heart failure and/or documented coronary artery disease. 133 51.1% START E4 – Bone anti-resorptive or anabolic therapy in patients with documented osteoporosis, where no pharmacological or clinical status contraindication exists and/or previous history of fragility fracture(s). 118 43.2% START H2 – Laxatives in patients receiving opioids regularly. 115 47.8% START E3 – Vitamin D and calcium supplement in patients with known osteoporosis and/or previous fragility fracture(s) and/or Bone Mineral Density T-scores more than -2.5 in multiple sites. 110 60.9% START E5 – Vitamin D supplement in older people who are housebound or experiencing falls or with osteopenia. 99 75.8%
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