330 CHAPTER 4.2 Figure 1. Summary of all consecutive steps (1-5) of the intervention within the OPERAM trial and the focus of this study highlighted: the agreement of recommendations by patients and attending physicians after discussion with the pharmacotherapy team (step 4). Data analyses Data analysis was performed with IBM SPSS® Statistics v.25.0.0.2. Baseline characteristics and agreement with STOPP/START recommendations were analysed using descriptive statistics. The outcome agreement was binary on a recommendation level (yes/no) and continuous on an individual patient level (percentage of recommendations agreed upon), as multiple recommendations could be applicable to one patient. Potential determinants of agreement were investigated on an individual patient level using a univariate and multivariate linear regression model (method: enter). For subgroup analyses on a recommendation level, relative risks (RR) and 95% confidence intervals (CIs) were calculated. P-values <0.05 were considered statistically significant. Results Study population A total of 452 patients were included in the OPERAM cohort at the Utrecht trial site, of whom 229 (50.7%) were allocated to the intervention group. Four patients (1.7%) withdrew from the trial prior to the intervention. The medication review including CDSS-assisted pharmacotherapy analysis was not completed in 23 of 225 patients (10.2%) due to several (mostly logistic) factors, such as early discharge, transfer to another ward (including the Intensive Care Unit) or to another hospital. Data from one patient were missing from the database. In 24 patients, the pharmacotherapy
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