334 CHAPTER 4.2 Figure 4. Top 10 START recommendations and corresponding agreement by patient and attending physician after discussion with PT. START E3 consist of recommendations for both calcium and/or vitamin D. START E2 consist of recommendations for calcium, vitamin D and/or bisphosphonates (i.e. Ca/Vit D/Bisph in the figure). Determinants of agreement Potential determinants of agreement were investigated on a patient level (N=139). Multivariate linear regression revealed three patient-related factors significantly associated with higher mean agreement (with STOPP/START recommendations taken together) i.e. female gender (+17.1% [3.7;30.4]), ≥1 falls in the past year (+15.0% [1.5;28.5]) and moderately diminished renal function defined as eGFR 30-50 ml/ min/1.73m2 (+18.0% [2.0;34.0]). None of the investigated setting-related factors (ward type, admission type, length of stay) was associated with lower/higher agreement. All determinants included in the univariate and multivariate analyses are displayed in Table 2. For the individual STOPP and START recommendations (N=371), potential determinants of agreement were investigated as well. No difference was found between STOPP and START recommendations and no significant relationship was found between the number of recommendations discussed (range 1-7) and subsequent agreement. All individual STOPP and START recommendations were categorised into subgroups according to the medication class involved and their occurrence. This resulted in 4 subgroups: 1) cardiovascular & antithrombotic agents (N=83;22.4%), 2) drugs for acid related disorders (N=61;16.4%), psychotropic drugs including benzodiazepines/Zdrugs (N=59;15.9%), 3) osteoporosis agents (vitamin D, calcium and bisphosphonates;
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