378 CHAPTER 4.3 Table SI1.1. Continued. Component Source Database Underuse START criteria v2 [1] + Expert opinion* 34 original START v2 criteria were converted into 33 algorithms. START A1 and A2 were merged into: ‘Start vitamin K antagonists, direct thrombin inhibitors or factor Xa inhibitors in the presence of chronic atrial fibrillation (START A1) or start aspirin instead if a vitamin K antagonist, direct thrombin inhibitor or factor Xa inhibitor is contraindicated (START A2)’. Overuse, misuse STOPP criteria v2 [1] + Expert opinion* 80 original STOPP v2 criteria were converted into 79 algorithms STOPP A2 (‘any drug prescribed beyond the recommended duration’) could not be coded Double medication Royal Dutch Society for the Advancement of Pharmacy (KNMP) database KNMP G-Standard was used to code STOPP A3 (‘any duplicate drug class prescription’) [11] Adverse drug reactions Expert opinion* SIDER v4 [12] Drug-drug interactions National interaction databases Switzerland – INDEX [13] Ireland – Safescript [14] Belgium – Delphi-Care [15] The Netherlands – KNMP G-Standard [11] Dose adjustments based on renal function Royal Dutch Society for the Advancement of Pharmacy (KNMP) database KNMP G-Standard [11] *i.e. expert opinion of a trained physician-pharmacist pair performing the pharmaceutical analysis. EHR = Electronic health record; SHiM = Structured History taking of Medication use.
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