39 Performance of a trigger tool for detecting adverse drug reactions Table 1. Continued. Original ADR trigger tool Explicated ADR trigger tool Trigger Associated drug Trigger Associated drug 5. Renal insufficiency A. ACE-I, ARB B. NSAIDs 5. Renal insufficiency and/or dehydrationb A. ACE-I, ARB B. NSAIDsb C. Thiazide diuretics, loop diuretics, potassium sparing diuretics 6. Disturbed serum glucose levels A. Blood glucose lowering agents B. Corticosteroids 6.1 Hypoglycaemia A. Oral antidiabetics, insulin and analogues 6.2 Hyperglycaemia B. Systemic corticosteroids 7. Heart failure A. NSAIDs 7. Acute heart failure A. NSAIDs 8. Constipation / ileus A. Opioids B. Calcium channel blockers 8. Constipation / ileus (based on constipation) A. Opioids B. Calcium channel blockers 9. Vomiting / diarrhoea A. Antibiotics 9. Vomiting / diarrhoea A. Antibiotics 10. Delirium/ confusion/ drowsiness A. Cardiac therapy B. Psychotropic agents C. Benzodiazepines D. Urinary antispasmodic agents 10. Delirium / confusion / drowsiness Drugs with anticholinergic and sedative properties (Supplementary Information SI1), digoxin, anti-Parkinson drugs aThe trigger ‘fall’ and its associated drug classes ‘psychotropic agents’ and ‘antihypertensive agents’ were merged in the explicated version of the ADR trigger tool with the trigger ‘collapse…’. bThe trigger dehydration and its associated drug class ‘NSAIDs’ was merged in the explicated version of the ADR trigger tool with the trigger ‘renal insufficiency’. ACE-I = angiotensin converting enzyme inhibitors, ARB = angiotensin II receptor blockers, SSRI = selective serotonin reuptake inhibitor, TCA = tricyclic antidepressant, DOAC = direct oral anticoagulant, NSAIDs = nonsteroidal anti-inflammatory drugs. 2
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