44 CHAPTER 2.1 Table 3. Number of ADRs per trigger and their associated drug classes, stratified for ADRs with a causal relationship considered to be possible, probable or certain, and for those considered to be probable or certain. RAAS = renin angiotensin aldosterone. ADR causality score: possible–probable–certain ADR causality score: probable–certain Trigger ADR, n (%) Drugs related to ADR (n) Recognition by usual care, % ADR, n (%) Drugs related to ADR (n) Recognition by usual care, % Fall / collapse / (orthostatic) hypotension/ dizziness / syncope 86 (21.9) Diuretics (17) Beta blocking agents (17) Agents acting on RAAS (17) Other (35) 66.3 14 (10.1) Diuretics (4) Psychoanaleptics (3) Beta blocking agents (2) Other (5) 100 Delirium / confusion / drowsiness 52 (13.2) Analgesics (21) Psycholeptics (9) Psychoanaleptics (7) Other (15) 75.0 15 (10.8) Analgesics (12) Antiepileptics (1) Anti-parkinson drugs (1) Cardiac therapy (1) 93.3 Renal insufficiency and/ or dehydration 94 (23.9) Diuretics (59) Agents acting on RAAS (27) Antiinflammatory and –rheumatic drugs (8) 89.4 28 (20.1) Diuretics (12) Agents acting on RAAS (9) Antiinflammatory and -rheumatic drugs (7) 96.4 Hyponatraemia 58 (14.8) Diuretics (44) Psychoanaleptics (9) Agents acting on RAAS (5) 96.6 24 (17.3) Diuretics (18) Psychoanaleptics (5) Agents acting on RAAS (1) 95.8 Constipation / ileus 24 (6.1) Analgesics (23) Calcium channel blockers (1) 91.7 13 (9.4) Analgesics (13) 92.3 Other bleedings 19 (4.8) Antithrombotic agents (17) Antiinflammatory and antirheumatics (2) 73.7 7 (5.0) Antithrombotic agents (7) 100 Hypoglycaemia 13 (3.3) Drugs used in diabetes (13) 100 10 (7.2) Drugs used in diabetes (10) 100 Hypokalaemia 14 (3.6) Diuretics (14) 92.9 5 (3.6) Diuretics (5) 100 Hyperkalaemia 9 (2.3) Diuretics (5) Agents acting on RAAS (4) 88.9 3 (2.2) Diuretics (2) Agents acting on RAAS (1) 100
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