126 Chapter 7 Results Patient characteristics and neonatal period In the period of 2012 – 2018, 588 infants were born in the LUMC or transferred to the NICU within 24 hours after birth, 293 infants in the pre-implementation period (pre-AOC) versus 295 infants in the post-implementation cohort (post-AOC). There were no differences in baseline characteristics (Table 1). In the neonatal period there were similar rates of IVH, PVL and laser coagulation for ROP. More details on the neonatal period can be found in our previous study.15 3 children were excluded from analysis due to major congenital abnormalities affecting neurodevelopment (2 preAOC, 1 post-AOC) and 4 were excluded because they moved to a different country (2 pre-AOC, 2 post-AOC) leaving 289 infants in the pre-AOC group and 292 infants in the post-AOC group. We were unable to obtain any follow-up data for 51 infants (preAOC 6.9% (20/289), post-implementation 10.6% (31/292), baseline characteristics Supplemental Table 1-2). Table 1. Patient characteristics and neonatal outcome Patient characteristics Pre-AOC n = 289 Post-AOC n = 292 p value* Gestational age in weeksdays, median [IQR] 282 [266 – 290] 280 [263 – 286] 0.09 Birth weight in grams, mean (SD) 1037 (291) 1037 (261) 1.00 Males, n (%) 162 (56.1) 155 (53.1) 0.47 Antenatal corticosteroids, n (%) 246 (86.0) 253 (87.5) 0.59 Caesarean delivery, n (%) 143 (49.5) 154 (52.7) 0.43 Multiple pregnancy, n (%) 115 (39.8) 97 (33.1) 0.10 of which monochorionic twins, n (%) 71 (61.7) 62 (63.9) 0.36 Perinatal asphyxia, n (%) 4 (1.4) 8 (2.7) 0.25 Apgar score at 5 minutes, median (range) 8 (2-10) 8 (1-10) 0.90 Intraventricular haemorrhage (≥ stage 2), n (%) 55 (19.0) 49 (16.8) 0.48 Periventricular leukomalacia (≥ stage 2), n (%) 4 (1.4) 6 (2.1) 0.53 Received laser coagulation for ROP, n (%) 13 (5.3) 14 (5.6) 0.85 Bronchopulmonary dysplasia severe, n (%) 36 (14.2) 48 (18.8) 0.10 moderate, n (%) 12 (4.7) 4 (1.6) mild, n (%) 44 (17.3) 37 (14.5) AOC, Automated Oxygen Control; ROP, Retinopathy of prematurity; *Statistical analysis with independent T-test, chi-square, nonparametric Mann-Whitney U test
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