79 4 Comparison of two AOCs in oxygen targeting in preterm infants during admission Figure 2. Average FiO2 excluding values FiO2<0.24 plotted against postnatal age. In the secondary analysis infants on OxyGenie spent 92.5 [91.8 – 97.2] % of the time within target range versus 90.2 [75.2 – 96.0] % of the time for infants on CLiO2 (p = 0.005, Table 4, Figure 3A per day, Figure 3B per week postmenstrual age). Contrary to the primary analysis, the differences were mainly attributed to a reduction in time under the target range, which was 5.0 [2.2 – 5.9] % in OxyGenie and 6.8 [3.3 – 13.6] % in CLiO2 (p = 0.003). Time above target range was similar (OxyGenie 2.0 [0.7 – 5.9], CLiO2 2.5 [0.4 – 10.9, p = ns). Major SpO2 deviations were less common in OxyGenie (SpO2 <80%: OxyGenie 0.2 [0.1 – 0.5] %, CLiO2 0.3 [0.2 – 0.8] %, p <0.001, Figure 3C; SpO2 >98%: OxyGenie 0.2 [0.1 – 0.6] %, CLiO2 0.4 [0.1 – 1.7] %, p <0.001, Figure 3D). The recorded average FiO2 was lower in the CLiO2 group (OxyGenie 23.0 [21.8 – 25.8] %, CLiO2 21.8 [21.1 – 24.8] %, p < 0.001).
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