Chapter 6 126 Magnesium sulfate vs Magnesium citrate No significant differences in vascular function markers (Table 5), blood pressure (Table 6) or plasma magnesium (Table 7) were observed between magnesium sulfate and magnesium citrate treatment. Urinary magnesium excretion was significantly lower at 12-wk and at 24-wk in the magnesium sulfate group (-0.96 mmol/24 h; 90% CI: -1.61; -0.32 mmol/24 h and -1.05 mmol/24 h; 90% CI: -1.69; -0.41 mmol/24 h, respectively). Plasma albumin was significantly higher in the magnesium sulfate group at 24-wk (Supplemental Table 6). No differences were observed between magnesium sulfate and magnesium citrate in terms of 24-urinary excretions of calcium, potassium, sodium and creatinine during the treatment period (Supplemental Table 7). Body weight and BMI were significantly higher after 24-wk of magnesium sulfate (0.8 kg; 90% CI: 0.2; 1.3 kg and 0.2 kg/m2; 90% CI: 0.1; 0.4 kg/m2) compared to magnesium citrate supplementation (Supplemental Table 8). Dietary and alcohol intake according to the food diaries did not change during the study period (Supplemental Table 9). Excluding non-compliant subjects as well as subjects on antihypertensive and/or lipid-lowering drugs did not materially change the results (data not shown). Table 5. Effects of magnesium oxide and magnesium sulfate (vs magnesium citrate) on vascular function markers. Magnesium oxide (n =46) Magnesium sulfate (n =46) Magnesium citrate (n=46) c-fPWV 2-wk Mean, m/s 8.5 ± 1.4 8.4 ± 1.4 9.1 ± 1.9 Difference vs magnesium citrate 0.0 (-0.4; 0.5) -0.4 (-0.9; 0.0) .. 12-wk Mean, m/s 8.5 ± 1.2 8.7 ± 1.7 9.0 ± 1.9 Difference vs magnesium citrate -0.0 (-0.5; 0.4) -0.1 (-0.5; 0.4) .. 24-wk Mean, m/s 8.4 ± 1.6 8.3 ± 1.4 9.0 ± 1.6 Difference vs magnesium citrate 0.1 (-0.5; 0.5) -0.4 (-0.8; 0.1) .. AI@HR75 2-wk Mean, % 21.7 ± 8.6 23.4 ± 8.5 25.0 ± 8.5 Difference vs magnesium citrate 0.4 (-1.2; 2.0) 0.8 (-0.8; 2.3) .. 12-wk Mean, % 20.8 ± 9.0 23.3 ± 9.1 25.3 ± 8.4 Difference vs magnesium citrate -0.4 (-2.0; 1.2) 0.1 (-1.5 1.7) ..
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