Chapter 6 138 introduced inter-operator variability. However, intra-subject variability was minimized by using the same operator for each single participant as much as possible. Conclusions In this RCT conducted in 164 overweight and slightly obese individuals, administering 450 mg of magnesium per day in an organic form (magnesium citrate) for 24-wk did not change arterial stiffness nor blood pressure. Furthermore, the inorganic formulations magnesium oxide and magnesium sulfate had similar non-significant effects on arterial stiffness and blood pressure. This indicates that magnesium supplements may not have beneficial effects on arterial stiffness, at least not in subjects with normal arterial stiffness values. It should be further elucidated whether long-term oral magnesium supplementation is effective in individuals with increased arterial stiffness, such as patients with chronic kidney disease. Acknowledgement None. Sources of Funding The study is supported by funding from the Nedmag Industries Mining and Manufacturing BV (NIMM) and the NIGRAM2+ collaboration project, financed by the PPP Allowance made available by Top Sector Life Sciences & Health to the Dutch Kidney Foundation to stimulate public–private partnerships.NIMM and NIGRAM2+ collaboration project had no input in the study design, data collection, analyses, or writing and submission of the article. Disclosures F. Goorman and R.M. Danel are employees of Nedmag Industries Mining and Manufacturing BV and Magnesium Health Institute, respectively. The other authors report no conflicts.
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