Lower plasma magnesium, measured by nuclear magnetic resonance spectroscopy, is associated with increased risk of developing type 2 diabetes mellitus in women: Results from a Dutch prospective cohort study 41 2 measured 1 year apart 49. Finally, because >95% of the subjects within the PREVEND study are white and of Dutch origin, the results may not be generalizable to different ethnic populations. Conclusion In summary, ionized Mg quantified on the Vantera Clinical Analyzer showed good agreement with total Mg measured on the Roche Modular Analyzer. In prospective analyses, we found that lower NMR-measured ionized Mg is associated with a higher risk of developing T2D in women, but not in men. This association was independent of several traditional T2D risk factors. These findings warrant future long-term clinical trials to study thoroughly the potential effects of Mg supplementation on prevention of T2D and T2D control. In addition, future studies should focus on the interaction between Mg and sex in the association with T2D. Authors contributions Conceptualization, J.C.S. , A.W.G.N. , G.N. , R.T.G. , M.H.D.B.; R.D. , F.G. and S.J.L.B.; Methodology, J.C.S, A.W.G.N. , E.J.J. , I.S. , J.D.O. , M.A.C. , and S.J.L.B.; Validation, J.C.S and A.W.G.N.; Formal Analysis, J.C.S and A.W.G.N; Investigation, J.C.S. and A.W.G.N.; Resources, J.E.K.-R.; Writing – Original Draft Preparation, J.C.S. and A.W.G.N.; Writing – Review & Editing, J.C.S. , A.W.G.N, G.N. , R.T.G. , R.P.F.D. , R.O.B.G. , M.H.D.B. , I.S. , J.D.O. , M.A.C. , S.J.L.B.; Supervision, M.H.D.B. and S.J.L.B. Funding This research received no external funding. Acknowledgments This work is supported by the NIGRAM2+ collaboration project, financed by the PPP Allowance made available by Top Sector Life Sciences & Health to the Dutch Kidney Foundation to stimulate public-private partnerships. Conflict-of-interest IS, JDO and MAC are employees of LabCorp.
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