Chapter 3 54 cells. To study the robustness of the associations between determinants and dIEM and iIEM, we performed sensitivity analyses with dIEM and iIEM expressed as mmol per liter packed blood cells (Supplemental Table 3). A two-sided p <0.05 was considered to be statistical significant. Data analyses were performed using SPSS 25.0 for Windows (SPSS Inc. , Chicago, IL) and Rstudio version 1.1.383 (Vienna, Austria). Results Baseline characteristics Baseline characteristics are shown in Table 1. Overall, mean age was 51.0 ± 13.4 years, 57.5% were female, 36.0% were non-smoker and 11.9% non-drinker. Mean BMI was 25.8 ± 4.3 kg/m2 and 32.2% of the participants had an eGFR <90 ml/min/1.73m2. Finally,mean plasma magnesium was 0.85 ± 0.06 mmol/L and mean urinary magnesium excretion was 4.85 ± 1.76 mmol/24-h. Table 1. Baseline characteristics of the LifeLines study. Characteristics Total (n=1669) Age, years 51.0 ± 13.4 Females, % 57.5 Anthropometry Body mass index, kg/m2 25.8 ± 4.3 Waist circumference, cm 89.9 ± 12.7 Smoking statusa Non-smoker, % 36.0 Former smoker, % 25.2 Current smoker, % 8.3 Alcohol consumptionb Non-drinker, % 11.9 ≤1 drink/day, % 38.3 1-2 drinks/day, % 14.1 ≥2 drinks/day, % 4.7 Magnesium parameters dIEM, mmol/1012 cells 0.20 ± 0.04 iIEM, mmol/1012 cells 0.25 ± 0.04 Plasma magnesium, mmol/L 0.85 ± 0.06 Urinary magnesium excretion, mmol/24-h 4.85 ± 1.76 Glucose metabolism Glucose, mmol/L 5.00 (4.70-5.40) HbA1c, mmol/mol 36.0 (34.0-38.0)
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