Comparison of two methods for the assessment of intra-erythrocyte magnesium and its determinants 59 3 Determinants of plasma magnesium Determinants of plasma magnesium are shown in Table 2. BMI, as well as glucose and HbA1c were inversely associated with plasma magnesium. Higher total- and LDL- cholesterol and triglyceride concentrations, as well as higher diastolic blood pressure were associated with higher plasma magnesium concentrations. Finally, eGFR <90 mL/ min/1.73m2 was associated with higher plasma magnesium concentrations. Subgroup analyses are presented in Table 3. Higher age was associated with higher plasma magnesium concentrations in females. In males, however, this association was found to be negative. The association of BMI with plasma magnesium was only present in older subjects (age ≥ 55 years). Furthermore, the association of HbA1c and plasma magnesium was stronger in males and older subjects (age ≥ 55 years). Subgroup analysis revealed that the positive association of triglycerides with plasma magnesium was only present in younger subjects (age < 55 years). Determinants of 24-h urinary magnesium excretion Determinants of 24-h urinary magnesium excretion are presented in Supplemental Table 1. Females showed lower 24-h urinary magnesium excretion compared to males. HDL cholesterol, and plasma potassium were positively associated with 24-h urinary magnesium excretion. eGFR of <90 mL/min/1.73m2 was negatively associated with 24-h urinary magnesium excretion. Subgroup analyses are shown in Supplemental Table 2. BMI and waist circumference were inversely associated with 24-h urinary magnesium excretion only in older subjects (age ≥ 55 years). In males, higher LDL cholesterol was associated with 24-h urinary magnesium excretion. The positive association of plasma potassium with 24-h urinary magnesium excretion was only present in younger subjects (age < 55 years).
RkJQdWJsaXNoZXIy MTk4NDMw