Comparison of two methods for the assessment of intra-erythrocyte magnesium and its determinants 63 3 dIEM,mmol/1012 cells iIEM,mmol/1012 cells Plasma magnesium,mmol/L Determinants Subgroup Univariable St. β (95% CI) Multivariable St. β (95% CI) Univariable St. β (95% CI) Multivariable St. β (95% CI) Univariable St. β (95% CI) Multivariable St. β (95% CI) eGFR < 90 ml/ min/1.73m2 Age < 55 .. .. .. .. 0.21 (0.06; 0.37)* 0.18 (0.02; 0.34)* Age ≥ 55 .. .. .. .. 0.08 (-0.11; 0.26) 0.17 (-0.03; 0.36) Males .. .. .. .. -0.05 (-0.21; 0.12) 0.01 (-0.19; 0.21) Females .. .. .. .. 0.33 (0.20; 0.47)** 0.20 (0.05; 0.35)* Creatinine clearance,mL/min Males .. .. .. .. -0.03 (-0.10; 0.05) -0.05 (-0.13; 0.03) Females .. .. .. .. -0.17 (-0.25; -0.09)** -0.08 (-0.16; 0.04) Plasma sodium, mmol/L Age < 55 0.15 (0.09; 0.22)** 0.13 (0.06; 0.19)** .. .. .. .. Age ≥ 55 0.12 (0.05; 0.20)* 0.12 (0.04; 0.19)* .. .. .. .. Hemoglobin, mmol/L Age < 55 0.10 (0.05; 0.16)** 0.12 (0.04; 0.20)* 0.11 (0.05; 0.16)** 0.14 (0.07; 0.22)** .. .. Age ≥ 55 0.01 (-0.08; 0.10) 0.09 (-0.01; 0.19) 0.00 (-0.09; 0.09) 0.05 (-0.05; 0.16) .. .. Males .. .. 0.04 (-0.06; 0.13) 0.04 (-0.06; 0.13) .. .. Females .. .. 0.23 (0.15; 0.31)** 0.17 (0.09; 0.25)** .. .. Hematocrit, v/v Age < 55 0.08 (0.02; 0.13)* 0.05 (-0.03; 0.13) .. .. .. .. Age ≥ 55 -0.01 (-0.09; 0.08) 0.02 (-0.08; 0.12) .. .. .. .. Males .. .. -0.04 (-0.13; 0.05) -0.05 (-0.14; 0.04) .. .. Females .. .. 0.16 (0.08; 0.24)** 0.09 (0.004; 0.17)* .. .. 1Associations presented in this table were significantlymodified by age and/or sex (all associations: P interaction <0.1).Multivariable models were adjusted for age, sex, BMI, eGFR (< 90 ml/min/1.73m2), plasma sodium and plasma potassium, and smoking and alcohol consumption.Abbreviations: dIEM, direct intra-erythrocyte magnesium; iIEM, indirect intra-erythrocyte magnesium; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c, MCV, mean corpuscular volume,*p <0.05, **p <0.001 Table 3. (Continued)
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