Comparison of two methods for the assessment of intra-erythrocyte magnesium and its determinants 73 3 Supplemental Table 3. Linear regression analyses with dIEM and iIEM (expressed as mmol/L) as dependent variables1 Determinant dIEM, mmol/L iIEM, mmol/L Univariable St. β (95% CI) Multivariable St. β (95% CI) Univariable St. β (95% CI) Multivariable St. β (95% CI) Age, years 0.09 (0.05; 0.14)** 0.00 (-0.07; 0.07) 0.07 (0.02; 0.11)* -0.05 (-0.11; 0.02) Sex, female -0.03 (-0.08; 0.02) -0.001; (-0.05; 0.05) -0.01 (-0.06; 0.04) 0.01 (-0.04; 0.06) Anthropometry Body mass index, kg/m2 0.12 (0.07; 0.16)** 0.10 (0.05; 0.15)** 0.18 (0.13; 0.23)** 0.17 (0.12; 0.21)** Waist circumference, cm 0.12 (0.07; 0.17)** 0.02 (-0.07; 0.12) 0.19 (0.15; 0.24)** 0.16 (0.07; 0.26)* Glucose metabolism Log10 Glucose, mmol/L 0.04 (-0.02; 0.09) -0.01 (-0.07; 0.04) 0.06 (0.01; 0.11)* 0.01 (-0.04; 0.07) Log10 HbA1c, mmol/mol 0.02 (-0.03; 0.07) -0.04 (-0.09; 0.02) 0.07 (0.02; 0.12)* 0.04 (-0.02; 0.09) Lipids metabolism Total cholesterol, mmol/L 0.10 (0.06; 0.15)** 0.07 (0.02; 0.12)* 0.11 (0.06; 0.16)** 0.08 (0.04; 0.13)* LDL cholesterol, mmol/L 0.10 (0.06; 0.15)** 0.07 (0.02; 0.12)* 0.10 (0.05; 0.14)** 0.07 (0.02; 0.11)* HDL cholesterol, mmol/L -0.08 (-0.12; -0.03)* -0.07 (-0.12; -0.01)* -0.11 (-0.16; -0.06)** -0.10 (-0.15; -0.04)** Log10 Triglycerides, mmol/L 0.14 (0.09; 0.18)** 0.11 (0.05; 0.16)** 0.19 (0.15; 0.24)** 0.15 (0.10; 0.21)** Blood pressure Systolic, mm Hg 0.06 (0.01; 0.10)* 0.01 (-0.05; 0.06) 0.10 (0.05; 0.14)** 0.04 (-0.01; 0.09) Diastolic, mm Hg 0.08 (0.03; 0.13)* 0.05 (-0.001; 0.10) 0.10 (0.05; 0.14)** 0.06 (0.01; 0.11)* Renal function eGFR < 90 ml/ min/1.73m2 0.15 (0.05; 0.25)* 0.05 (-0.07; 0.17) 0.12 (0.02; 0.22)* 0.05 (-0.07; 0.16) Creatinine clearance, mL/min -0.02 (-0.07; 0.03) -0.03 (-0.08; 0.03) -0.02 (-0.06; 0.03) -0.04 (-0.10; 0.01) Plasma levels Sodium, mmol/L 0.11 (0.07; 0.16)** 0.10 (0.05; 0.15)** 0.11 (0.06; 0.16)** 0.10 (0.05; 0.15)** Potassium, mmol/L 0.12 (0.08; 0.17)** 0.11 (0.06; 0.15)** 0.05 (-0.002; 0.09) 0.03 (-0.02; 0.08) Hematology Hemoglobin, mmol/L 0.12 (0.07; 0.17)** 0.15 (0.09; 0.21)** 0.13 (0.08; 0.18)** 0.17 (0.11; 0.23)** Hematocrit, v/v 0.09 (0.05; 0.14)** 0.07 (0.02; 0.13)* 0.07 (0.02; 0.12)* 0.05 (-0.01; 0.11) MCV, fL 0.02 (-0.02; 0.07) 0.01 (-0.04; 0.06) -0.02 (-0.07; 0.03) -0.02 (-0.07; 0.03) Multivariable models were adjusted for age, sex, BMI, eGFR (< 90 ml/min/1.73m2), plasma sodium and plasma potassium, and smoking and alcohol consumption. Abbreviations: dIEM, direct intraerythrocyte magnesium; iIEM, indirect intra-erythrocyte magnesium; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c, MCV, mean corpuscular volume,*p <0.05, **p <0.001
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