193 Preferences of Sjögren’s syndrome patients for saliva substitutes Table 3: Sjögren’s syndrome patients’ opinion regarding the desired flavours of saliva substitutes, using a Likertscale (from 1= “Unimportant’’ to 5= “Very important’’). Patients were stratified in subgroups based on their age and severity of xerostomia. For the total study population, the data are expressed as mean score with standard deviation (SD.) and as median scores with the corresponding interquartile range (IQR). For both ages groups and XI-groups the mean score with SD. were reported. N indicates the number of participants in each group. Possible flavours Total mean ± SD. (N) Total median ± IQR Birthyear ≤1958 (N) Birthyear ≥1959 (N) p-value* XI-score ≤46 (N) XI-score ≥47 (N) p-value* Strawberry 1.81 ± 1.27 (N=57) 1.0 ± 1.0-3.0 1.77 ± 1.24 (N=26) 1.84 ± 1.32 (N=31) 0.55 1.79 ± 1.18 (N=29) 1.82 ± 1.39 (N=28) 0.54 Apple 2.03 ± 1.36 (N=58) 1.0 ± 1.0-3.0 1.89 ± 1.31 (N=27) 2.16 ± 1.42 (N=31) 0.29 2.17 ± 1.47 (N=29) 1.90 ± 1.26 (N=29) 0.40 Banana 1.82 ± 1.31 (N=57) 1.0 ± 1.0-3.0 1.77 ± 1.24 (N=26) 1.87 ± 1.38 (N=31) 0.49 1.86 ± 1.27 (N=29) 1.79 ± 1.37 (N=28) 0.38 Blueberry 2.09 ± 1.43 (N=56) 1.0 ± 1.0-3.0 2.08 ± 1.50 (N=26) 2.10 ± 1.40 (N=30) 0.64 2.41 ± 1.57 (N=29) 1.74 ± 1.20 (N=27) 0.03 Lemon 2.31 ± 1.50 (N=58) 1.5 ± 1.0-4.0 2.33 ± 1.59 (N=27) 2.29 ± 1.44 (N=31) 0.83 2.69 ± 1.54 (N=29) 1.93 ± 1.39 (N=29) 0.05 Cola 1.49 ± 1.12 (N=57) 1.0 ± 1.0-1.0 1.54 ± 1.21 (N=26) 1.45 ± 1.06 (N=31) 0.56 1.59 ± 1.24 (N=29) 1.39 ± 0.99 (N=28) 0.34 Liquorice 1.81 ± 1.37 (N=57) 1.0 ± 1.0-2.5 1.81 ± 1.36 (N=26) 1.81 ± 1.40 (N=31) 0.75 1.79 ± 1.37 (N=29) 1.82 ± 1.39 (N=28) 0.66 Menthol/ spearmint 3.57 ± 1.55 (N=58) 4.0 ± 3.0-5.0 2.96 ± 1.53 (N=27) 4.10 ± 1.38 (N=31) 0.003 3.66 ± 1.50 (N=29) 3.48 ± 1.62 (N=29) 0.58 No flavour 3.91 ± 1.58 (N=57) 5.0 ± 3.0-5.0 3.88 ± 1.68 (N=26) 3.94 ± 1.53 (N=31) 0.65 3.79 ± 1.66 (N=29) 4.04 ± 1.53 (N=28) 0.89 Neutral flavour 3.98 ± 1.47 (N=58) 5.0 ± 3.0-5.0 3.93 ± 1.57 (N=27) 4.03 ± 1.40 (N=31) 0.74 3.52 ± 1.64 (N=29) 4.45 ± 1.12 (N=29) 0.02 *: p-value of the Mann-Whitney U test 9
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